Physical and functional interactions between STAP-2/BKS and STAT5.

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概要

• 論文の詳細を見る

• Signal-transducing adaptor protein family of proteins (STAPs), which currently contains two members, are proposed to be adaptor molecules because of their pleckstrin homology (PH) and Src-homology 2 (SH2)-like domains. STAP-1 has been shown to interact with STAT5 and the tyrosine kinase Tec. With regard to STAP-2/BKS functions, immunoprecipitation experiments and intracellular stainings revealed STAP-2/BKS binds STAT5 in several types of cells. Mutational studies revealed that the PH- and SH2-like domains of STAP-2/BKS interacted with the C-terminal region of STAT5. STAP-2/BKS and STAT5 were found to constitutively co-localize in the cytoplasm of resting cells, but STAP-2/BKS was found to dissociate upon STAT5 phosphorylation, suggesting a role in regulating signaling of STAT5. The physiological role of these interactions is not fully understood, but in studies of overexpression of STAP-2/BKS, cytokine-induced tyrosine phosphorylation and transcriptional activation of STAT5 was diminished. In addition, thymocytes from STAP-2/BKS-deficient mice showed the enhanced interleukin-2-dependent cell growth. Taken together, STAP-2/BKS is an additional modulator of STAT5-mediated signaling.

• American Society for Biochemistry and Molecular Biologyの論文
• 2005-03-04

著者

• Shimoda Kazuya

  九州大学 第1内科

• Yamamoto Yu

  北海道大学 薬学研究院衛生化学

• Asano Y

  Department Of Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University

• Shinagawa Katsuji

  岡山大学 第2内科

• Oritani K

  Osaka Univ. Osaka Jpn

• Oritani Kenji

  大阪大学 血液･腫瘍内科学

• Shimoda Kazuya

  Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers

• Sunami Kazutaka

  Division Of Hematology Department Of Internal Medicine National Hospital Organization Okayama Medica

• Shimoda Kazuya

  Medicine And Biosystemic Science Graduate School Of Medical Sciences Kyushu University

• Matsuda Tadashi

  Department Of Immunology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Sugiyama Kenji

  Department Of Internal Medicine Gastroenterology And Hematology Faculty Of Medicine Miyazaki Univers

• Sugio Y

  Miyazaki Prefectural Miyazaki Hospital Miyazaki Jpn

• Abe Yasunobu

  Department Of Microbiology And Immunology Keio University School Of Medicine

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