Tom1 (Target of Myb 1) Is a Novel Negative Regulator of Interleukin-1- and Tumor Necrosis Factor-Induced Signaling Pathways (Biochemistry/Molecular Biology)
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概要
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The Tom1 (target of Myb 1) protein has VHS and GAT domains in N-terminal and central parts, respectively. The VHS domain has been found in a number of proteins, some of which have been implicated in intracellular trafficking and sorting. We previously showed that Toml forms a complex with Tollip, which has been reported to function in interleukin-1 (IL-1)-dependent signaling. In this study, we carried out a reporter gene assay to investigate the function of Toml in inflammatory cytokine-dependent signaling. It was found that overexpression of Tom1 suppresses activation of transcription factors, NF-кB and AP-1, induced by either IL-1β or tumor necrosis factor (TNF)-α and that the VHS domain of Tom1 is indispensable for its suppressive activity. Thus, we propose that Tom1 is a common negative regulator of the signaling pathways induced by IL-1β and TNF-α.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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YOKOSAWA Hideyoshi
Department of Biochemistry, Faculty of Pharmacological Science, Hokkaido University
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Yokosawa Hideyoshi
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yokosawa H
Graduate School Of Pharmaceutical Sciences Hokkaido University
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YAMAKAMI Megumi
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Yokosawa Hideyoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Yamakami Megumi
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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