Girolline, an Antitumor Compound Isolated from a Sponge, Induces G2/M Cell Cycle Arrest and Accumulation of Polyubiquitinated p53 (Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
Girolline, an antitumor compound isolated from a sponge, has been reported to inhibit the termination step of protein synthesis in vivo. In this study, we found that girolline induced G2/M cell cycle arrest in several tumor cell lines. Immunochemical analysis revealed that polyubiquitinated p53 was accumulated in girolline-treated cells, while other polyubiquitinated cellular proteins were not accumulated, indicating that the effect of girolline is specific for p53. On the other hand, girolline did not inhibit proteasome activity in vitro, and accumulation of polyubiquitinated p53 was scarcely detected in the presence of leptomycin B, an inhibitor of nuclear export. Based on the above findings, we propose that girolline affects the step of recruitment of polyubiquitinated p53 to the proteasome.
- 公益社団法人日本薬学会の論文
- 2004-05-01
著者
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YOKOSAWA Hideyoshi
Department of Biochemistry, Faculty of Pharmacological Science, Hokkaido University
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Matsunaga Shigeki
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences,
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Fusetani Nobuhiro
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences,
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Yamashita Katsumi
Faculty of Engineering, University of the Ryukyus
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OHTA Tomihisa
Faculty of Pharmaceutical Sciences, Kanazawa University
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TSUKAMOTO Sachiko
Faculty of Pharmaceutical Sciences, Kanazawa University
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Ohta T
Graduate School Of Natural Science And Technology Kanazawa University
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Ohta Tomihisa
Faculty Of Pharmaceutical Sciences Kanazawa University
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Kizu Ryoichi
Faculty of Pharmaceutical Sciences, Doshisha Women's College
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Kawahara Hiroyuki
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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Fusetani Nobuhiro
Laboratory Of Aquatic Natural Products Chemistry Graduate School Of Agricultural And Life Sciences T
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Sachiko Tsukamoto
Graduate School Of Natural Science And Technology Kanazawa University
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Tsukamoto Sachiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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Yokosawa Hideyoshi
Department Of Biochemistry Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yokosawa Hideyoshi
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Yamashita Katsumi
Faculty Of Pharmaceutical Sciences Kanazawa University
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TANE Kazuhiro
Faculty of Pharmaceutical Sciences, Kanazawa University
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Yokosawa H
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Kizu Ryoichi
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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Tane Kazuhiro
Faculty Of Pharmaceutical Sciences Kanazawa University
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Fusetani Nobuhiro
Lab. Of Aquatic Natural Products Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Yamashita Katsumi
Faculty Of Engineering University Of The Ryukyus
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Matsunaga Shigeki
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Matsunaga Shigeki
Laboratory Of Aquatic Natural Products Chemistry Graduate School Of Agricultural And Life Sciences T
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Yokosawa Hideyoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Matsunaga Shigeki
Lab. Of Aquatic Natural Products Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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