7-Hydroxy-3-(4-hydroxybenzyl) chroman and Broussonin B : Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors(Pharmacognosy)
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概要
- 論文の詳細を見る
The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2, 6, 4'-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis-hinokiresinol (4). Compounds 1-3 induced neurite outgrowth in PC-12 cells at concentration of 50μg/ml, while 4 was less active. In addition, compounds 2-4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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Ohta Tomihisa
Graduate School Of Natural Science And Technology Kanazawa University
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Ohta T
Graduate School Of Natural Science And Technology Kanazawa University
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Sachiko Tsukamoto
Graduate School Of Natural Science And Technology Kanazawa University
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Tsukamoto Sachiko
Graduate School Of Natural Science And Technology Kanazawa University
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Yoshida Takushi
Graduate School of Natural Science and Technology, Kanazawa University
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WAKANA Takeshi
Graduate School of Natural Science and Technology, Kanazawa University
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KOIMARU Keiichirou
Graduate School of Natural Science and Technology, Kanazawa University
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SATO Mako
Graduate School of Natural Science and Technology, Kanazawa University
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Sato Mako
Graduate School Of Natural Science And Technology Kanazawa University
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Wakana Takeshi
Graduate School Of Natural Science And Technology Kanazawa University
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Yoshida Takushi
Graduate School Of Natural Science And Technology Kanazawa University
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Koimaru Keiichirou
Graduate School Of Natural Science And Technology Kanazawa University
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