Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor
スポンサーリンク
概要
- 論文の詳細を見る
Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC50 values of 50 and 32 μg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 μg/ml.
著者
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KOBAYASHI Hisayoshi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Nagasawa Yumiko
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Ueoka Reiko
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Yamanokuchi Rumi
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Horiuchi Naoki
Graduate School of Science, Chiba University
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Ikeda Tsuyoshi
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Rotinsulu Henki
Faculty of Agriculture, Universitas Pembangunan Indonesia
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Mangindaan Remy
Faculty of Fisheries and Marine Science, Sam Ratulangi University
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Ukai Kazuyo
Tohoku Pharmaceutical University
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Namikoshi Michio
Tohoku Pharmaceutical University
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Hirota Hiroshi
RIKEN Genomic Sciences Center
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Yokosawa Hideyoshi
School of Pharmacy, Aichi Gakuin University
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Tsukamoto Sachiko
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Mangindaan Remy
Faculty Of Fisheries And Marine Science Sam Ratulangi University
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Namikoshi Michio
Tohoku Pharmaceutical Univ. Sendai Jpn
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Tsukamoto Sachiko
Graduate School Of Natural Science And Technology Kanazawa University
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Ueoka Reiko
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Ikeda Tsuyoshi
Graduate School Of Pharmaceutical Sciences Faculty Of Life Sciences Kumamoto University
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Hirota Hiroshi
Riken
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Kobayashi Hisayoshi
Institute of Molecular and Cellular Biosciences, University of Tokyo
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