Melophlins P, Q, R, and S : Four New Tetramic Acid Derivatives, from Two Palauan Marine Sponges of the Genus Melophlus

スポンサーリンク

概要

• 論文の詳細を見る

• Four new tetramic acid derivatives, named melophlins P, Q, R, and S (1-4), were isolated from two marine sponges of the genus Melophlus collected at Palau, together with seven known melophlins A, D, E, G, H, I, and O. The structures of the new compounds were elucidated on the basis of their spectral data. The absolute stereochemistries at the tetramic acid moieties of the new compounds were determined as 1:1 mixtures (racemic) by ESI-LC/MS analysis of derivatives obtained by oxidation and hydrolysis of the respective parent compounds. Melophlins P-S (1-4) showed cytotoxicity against the murine leukemia cell line L1210 with IC_<50> values of 20.0, 10.5, 0.85, and 5.13μM, respectively.

• 公益社団法人日本薬学会の論文
• 2006-06-01

著者

• Nagai Hiroshi

  Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Me

• KOBAYASHI Hisayoshi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Komatsu H

  School Of Agriculture Kyushu Tokai University

• Namikoshi Michio

  Tohoku Pharmaceutical University

• Komatsu H

  Kyoto Pharmaceutical University

• HARADA Ken-ichi

  Graduate School of Environmental and Human Sciences and Faculty of Pharmacy, Meijo University

• Nagai Hiroshi

  Department Of Cardiology Regeneratiion Medicine And Bioethics Gifu University Graduate School Of Med

• NAMIKOSHI Michio

  Department of Ocean Sciences, Tokyo University of Fisheries

• Kobayashi Hiroki

  Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University

• Namikoshi Michio

  Department Of Ocean Sciences Tokyo University Of Fisheries

• Namiki Mikie

  Department Of Ocean Sciences Tokyo University Of Fisheries

• Namikoshi Michio

  Department Of Ocean Science Tokyo University Of Marine Science And Technology

• Namikoshi Michio

  Department Of Natural Products Chemistry Tohoku Pharmaceutical University

• Nagai Hiroshi

  Department Of Ocean Sciences Tokyo University Of Marine Science And Technology

• Kobayashi H

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• XU Jinzhong

  Department of Ocean Sciences, Tokyo University of Marine Science and Technology

• Xu Jinzhong

  Tohoku Pharmaceutical University

• Xu Jinzhong

  Department Of Mathematics University Of Kentucky

• HASEGAWA Masateru

  Graduate School of Environmental and Human Sciences, Meijo University

• Nagai H

  Department Of Ocean Sciences Tokyo University Of Marine Science And Technology

• Natori Masahiko

  College Of Agriculture And Veterinary Medicine Nihon University

• Harada Ken-ichi

  Graduate School Of Environmental And Human Sciences Meijo University:faculty Of Pharmacy Meijo Unive

• Harada Ken-ichi

  Graduate School Of Environmental And Human Science & Faculty Of Pharmacy Meijo University

• Hasegawa Masateru

  Graduate School Of Environmental And Human Sciences Meijo University

• Hasegawa Masateru

  Graduate School Of Environmental And Human Science Meijo University

• Nagai Hiroshi

  Department Of Anatomy Okayama University Sohool Of Dentistry

• Nagai Hiroshi

  Department Of Anatomy Okayama University School Of Dentistry

• HASEGAWA MASATERU

  Graduate School of Environmental and Human Science and Faculty of Pharmacy, Meijo University

関連論文

• Coordination of Divalent Metal Cation to Amide Group to Form Adduct Ion in FAB Mass Spectrometry: Implication of Zn^ in Enzymatic Hydrolysis of Amide Bond
• Granulocyte Colony-Stimulating Factor : A Noninvasive Regeneration Therapy for Treating Atherosclerotic Peripheral Artery Disease
• Microstructure and Thermoelectric Properties of NaxCo2O4 Synthesized by Spark Plasma Sintering (特集 熱電変換材料)
• Effect of Partical Substitution of 3d Transition Metals for Co on the Thermoelectric Properties of Na_xCo_2O_4
• Preparation of SiC Dispersed Fe_Co_Si_2 by Pressureless Sintering with Cu and Si Addition and Its Thermoelectric Performance
• 液相焼結法によるβ-FeSi_2の作製とその熱電特性
• Effects of Al and Cu Addition on Pressureless Sintering behavior and Phase Transformation of β-FeSi_2
• Effect of Si/C Ratio on thermoelectric Properties of β-FeSi_2 Mechanically Alloyed with (Si+C) Additions
• Thermoelectric Properties of β-FeSi_2 Mechanically Alloyed with Si and C
• Effects of Mechanical Alloying and Copper Addition on Thermoelectric Properties of n-Type and p-Type β-FeSi_2
• Improvement of Magnetic Properties of Mechanically Ground Sm_2Fe_N_x Powders by Vacuum Heat Treatment
• Effect of Milling Atmosphere on the Preparation of Sm_2Fe_N_x Powder by Mechanical Grinding
• Delta(9)-tetrahydrocannabinol Enhances an Increase of Plasma Corticosterone Levels Induced by Forced Swim-Stress
• Effectiveness of Iron Clusters as Pinning Centers in the YBa_2(Cu_Fe_x)_3O_y System
• Japanese VLBI Network Observations of Radio-Loud Narrow-Line Seyfert 1 Galaxies
• Accelerated Post-infarct Neovascularization and Tissue Repair by Chemotherapy-combined G-CSF May Be Related to Peripheral CD34^+ Cells Increased via CXCR4-SDF-1 Axis(Apoptosis/Necrosis/Regeneration 1 (M), The 69th Annual Scientific Meeting of the Japanese
• PE-270 Intravenous Transplantation of Autologous Bone Marrow-Derived Mononuclear Cells Improves Cardiac Function via Downregulation of TGF-beta and TNF-alpha in Ischemia-Reperfusion Hearts.(Transplantation 1 (M) : PE46)(Poster Session (English))
• OE-110 G-CSF after Transient Myelosuppression Improves Cardiac Function via More Myocardial Regeneration and Vasculogenesis than G-CSF Alone in Ischemia-Reperfusion Hearts(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
• Nicorandil Has a Free Radical Scavenging Effect through Opening the Mitochondrial KATP Channels during Ischemia and Reperfusion in Rabbits
• Miglitol Reduces Myocardial Infarct Size via Scavenging Hydroxyl Radicals, Enhancing Bel-XL Expression and Reducing Bax Expression in Rabbits
• HGF Gene Transfer Reduces Myocardial Infarct Size through Decreasing Hydroxyl Radicals Production and Enhancing Expression of BcI-2 in Rabbits
• G-CSF Treatment after Myocardial Infarction Improves Left Ventricular Function and Remodeling Even at 3 Months after Infarction
• Two Novel Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Derivatives from the Fruit of Vaccinium uliginosum
• A New Triterpene Glucosyl Ester from the Fruit of the Blackberry (Rubus allegheniensis)
• Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Ester, Vaccihein A, from the Fruit of Rabbiteye Blueberry (Vaccinium ashei)
• Isolation of salsolinol, a Tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor
• Structural characterization of plancitoxin I, a deoxyribonuclease II-like lethal factor from the crown-of-thorns starfish Acanthaster planci, by expression in Chinese hamster ovary cells
• Medicinal Foodstuffs. VI. Histamine Release Inhibitors from Kidney Bean, the Seeds of Phaseolus vulgaris L : Chemical Structures of Sandosaponins A and B
• Novel Magnesium-Manganese Hydrides Prepared by the Gigapascal High Pressure Technique
• Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor
• Clinical Relevance of Survivin as a Biomarker in Neoplasms, Especially in Adult T-Cell Leukemias and Acute Leukemias
• Structure Determination of Ribosylated Rifampicin and Its Derivative:New Inactivated Metabolites of Rifampicin by Mycobacterial Strains
• Isolation and Structures of an Antifungal Antibiotic, Fusarielin A, and Related Compounds Produced by a Fusarium sp.
• VLBI Observations of the Most Radio-Loud, Narrow-Line Quasar SDSS J094857.3+002225
• -0449-EVALUATION OF SEVERITY OF PATIENTS WITH MYOCARDIAL INFARCTION USING ANAEROBIC THRESHOLD
• Identification of Protein Disulfide Isomerase as a Phorbol Ester-Binding Protein
• OJ-179 Long Term Effect of Granulocyte Colony-Stimulating Factor as a Novel and Noninvasive Regeneration Therapy Against Atherosclerotic Peripheral Artery Disease(Peripheral Circulation/Vascular Disease 1 (H) : OJ21)(Oral Presentation (Japanese))
• Recent Progress in Jellyfish Toxin Study
• Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule I.Taxonomy, Fermentation, Isolation and Biological Activities
• Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions : another possible model for atopic dermatitis
• Phenopyrrozin, a New Radical Scavenger Produced by Penicillium sp.FO-2047
• Phenochalasins, Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Phomopsis sp. FT-0211
• Cytotoxic Triterpenes and Sterol from the Fruit of Rabbiteye Blueberry (Vaccinium ashei)
• Macrosphelides C and D, Novel Inhibitors of Cell Adhesion
• Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule II. Physicochemical Properties and Structural Elucidation
• Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent : Basic Biological Characterization
• Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton
• Mono- and Dihydroxylated Metabolites of Thalidomide : Synthesis and TNF-α Production-Inhibitory Activity
• Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis
• Enhancement of All-trans Retinoic Acid-Induced HL-60 Cell Differentiation by Thalidomide and Its Metabolites(Communication to the Editor)
• Conversion of Ca^ Salt of an Organic Compound to Its Li^+ Salt to Simplify the Fast Atom Bombardment Mass Spectrum
• Coordination of Sodium Cation to an Oxygen Function and Olefinic Double Bond to Form Molecular Adduct Ion in Fast Atom Bombardment Mass Spectrometry
• Argifin, a New Chitinase Inhibitor, Produced by Gliocladium sp. FTD-0668 : I. Taxonomy, Fermentation, and Biological Activities
• Collisionally Activated Dissociation of 13-Membered Peptides, Ustiloxins, and Phomopsins
• Structural Identification of a Major Cytokinin in Coconut Milk as 14-O-{3-O-[β-D-Galactopyranosyl-(1→2)-α-D-galactopyranosyl-(1→3)-α-L-arabinofuranosyl]-4-O-(α-L-arabinofuranosyl)-β-D-galactopyranosyl}trans-zeatin Riboside
• Promotion of IL-8 production in PMA-stimulated HL-60 cells by sesquiterpene quinones from a marine sponge, Hippospongia sp.
• P-175 STRUCTURES AND BIOLOGICAL ACTIVITIES OF SESQUITERPENE QUINONES FROM A PALAUAN MARINE SPONGE
• Synthesis, Conformation, and Chemical Properties of New Mini Parallel Double-Stranded Peptides Conjugated with -Phe-Phe- and -Phe-Phe-X- Sequences
• A Simple Quantitative Measurement of mRNA of Human β-actin by Reverse Transcription Competitive PCR with a Compact Digital Camera
• Cytotoxicity of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, against Human Solid-Tumor-Derived Cell Lines(Pharmacognosy)
• P-391 STRUCTURE AND BIOACTIVITY OF LISSOCLIBADINS ISOLATED FROM A TROPICAL ASCIDIAN LISSOCLINUM CF. BADIUM
• In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin
• Medicinal Foodstuffs. IV. Fenugreek Seed. (1) : Structures of Trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, New Furostanol Saponins from the Seeds of Indian Trigonella foenum-graecum L.
• Anomalous Electrical Resistivity of Bi-Sr-Ca-Cu-O System at High Temperature
• Enzyme Histochemical Study on the Thyroid C-cells in the Sika Deer (Cervus nippon)
• Enzyme Histochemical Studies on the Parathyroid Gland and Thyroid C-cells in the Common Dolphin (Delphinus Delphis)
• P-64 New Cyclic Depsipeptides from the Hawaiian Green Alga Bryopsis Species : Utilization of Carboxypeptidase for the Absolute Stereostructure Determination
• 12'-Hydroxyl group remarkably reduces Roridin E cytotoxicity
• Tetrahydrobostrycin and 1-Deoxytetrahydrobostrycin, Two New Hexahydroanthrone Derivatives, from a Marine-derived Fungus Aspergillus sp.
• Three New Nardosinane Type Sesquiterpenes from an Indonesian Soft Coral Nephthea sp.
• CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes
• Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration
• Microbubble-enhanced ultrasound for gene transfer into living skin equivalents
• Four New Macrocyclic Trichothecenes from Two Strains of Marine-derived Fungi of the Genus Myrothecium
• P-147 MELOPHLINS P-S, NEW TETRAMIC ACID DERIVATIVES, FROM TWO MARINE SPONGES OF THE GENUS MELOPHLUS COLLECTED IN PALAU
• Melophlins P, Q, R, and S : Four New Tetramic Acid Derivatives, from Two Palauan Marine Sponges of the Genus Melophlus
• Prevention by Polyhydroxysteroids and Saponins of Asterina pectinifera of the Desquamation of Stratum Corneum Cells(Organic Chemistry)
• Identification of Streptomyces and Kitasatospora strains from Thai soils with geldanamycin production strain
• Selective and Potent in Vitro Antitrypanosomal Activities of Ten Microbial Metabolites
• In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca
• Manoalide derivatives from a marine sponge Luffariella sp. collected in Palau
• Three New Chlorine Containing Antibiotics from a Marine-derived Fungus Aspergillus ostianus Collected in Pohnpei
• A New Screening Method for Antimitotic Substances and Isolation of Glycolipids as Stimulators of Tubulin Polymerization from Okinawan Sponge Pseudoceratina sp.
• Effect of sea water concentration on hyphal growth and antimicrobial metabolite production in marine fungi
• Cladospolide D, a New 12-Membered Macrolide Antibiotic Produced by Cladosporium sp. FT-0012
• Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554
• Isolation and Characterization of Bioactive Metabolites form Marine-Derived Filamentous Fungi Collected from Tropical and Sub-Tropical Coral Reefs
• Structure Elucidation of Roselipins, Inhibitors of Diacylglycerol Acyltransferase Produced by Gliocladium roseum KF-1040
• Roselipins, Inhibitors of Diacylglycerol Acyltransferase, Produced by Gliocladium roseum KF-1040
• Roselipins, Novel Fungal Metabolites Having a Highly Methylated Fatty Acid Modified with a Mannose and an Arabinitol
• Simaomicin α: Effects on the Cell Cycle of Synchronized, Cultured Plasmodium falciparum
• Medicinal Foodstuffs. XII. Saponin Constituents with Adjuvant Activity from Hyacinth Bean, the Seeds of Dolichos lablab L. (1) : Structures of Lablabosides A, B, and C
• Homoisoflavonoids and Related Compounds. V. : A Novel Dibenzoxocin Derivative from Caesalpinia sappan L.(Organic,Chemical)
• Two New Pregnane Glycosides from Dioscorea futschauensis R. KUNTH
• Diastereomeric Selective Effects for Growth Inhibition of Synthesized Mini Parallel Double-Stranded Peptides on Escherichia coli and Staphylococcus aureus
• Skin cancer screening in Okinawa, Japan
• Identification of Binding Proteins of Fusarielin A as Actin and Tubulin
• Paecilospirone, a Unique Spiro [chroman-2, 1' (3'H)-isobenzofuran] Derivative Isolated from Tropical Marine Fungus Paecilomyces sp.^H
• Phomopsidin, a New Inhibitor of Microtubule Assembly Produced by Phomopsis sp. isolated from Coral Reef in Pohnpei
• A Screening Method for Antimitotic and Antifungal Substances Using Conidia of Pyriculaia oryzae, Modification and Application to Tropical Marine Fungi

もっと見る 閉じる

スポンサーリンク