Identification of Protein Disulfide Isomerase as a Phorbol Ester-Binding Protein

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概要

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• A specific binding protein for 12-O-tetradecanoylphorbol 13-acetate (TPA), different from protein kinase C (PKC) and histone H1,was purified from HeLa cell extract by the use of affinity gel pendanted with phorbol ester (TPA-GEL). The purified binding protein was identified as protein disulfide isomerase (PDI, EC 5.4.3.1) by peptide sequence analysis. The dissociation constants (K_d's) of TPA to PDI, histone H1 and PKCα were determined to be 1.03×10^<-6>M, 5.70×10^<-7>M, and 4.00×10^<-7>M, respectively, by the surface plasmon resonance (SPR) method. TPA moderately inhibited PDI activity assessed in terms of reactivation of denatured RNase A.

• 社団法人日本薬学会の論文
• 2000-09-01

著者

• 遠藤 泰之

  東北薬科大学薬学部

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• KOBAYASHI Hisayoshi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• ENDO Yasuyuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• MAYUMI Satoshi

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• AZUMA Akihiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• SODEOKA Mikiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• YANO Keiichi

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• SUGIMOTO Seiji

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Yano K

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Yano Keiichi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Azuma Akihiko

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Sugimoto Seiji

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Mayumi Satoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Sodeoka Mikiko

  Sagami Chemical Research Center

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Sugimoto Seiji

  Tokyo Research Laboratories Kyowa Hakko Co. Ltd.

• Endo Yasuyuki

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

• Sodeoka Mikiko

  Institute for Chemical Reaction Science, Tohoku University

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