POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON

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概要

• 論文の詳細を見る

• 4-[N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss or differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC_<50> (SEC_<50>) values of DA023 (11,1.6×10^<-10> M) and DA113 (14,1.4×10^<-10> M) in the presence of 1.0×10^<-10> M Am80 (2).

• 公益社団法人日本薬学会の論文
• 1998-05-15

著者

• FUKASAWA Hiroshi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• KAGECHIKA Hiroyuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• TSUJI Motonori

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• OHTA Kiminori

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• KAWACHI Emiko

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Shudo K

  Research Foundation Itsuu Laboratory

• Fukasawa Hiroshi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Ohya Kumiko

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Tsuji M

  Univ. Tokyo Tokyo Jpn

• Tsuji Motonori

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

• Fukasawa H

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

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