New-Type Inducers of Differentiation of HL-60 Leukemia Cells Suppress c-myc Expression(Medeicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
New-type inducers of differentiation of human promyelocytic leukemia cells HL-60, i.e., 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthaIenyIcarbamoyl)benzoic acid (Am 80) and (E)-4-[3-(3,5-di-tert-butyIphenyl)-3-oxo-1-propenyl]benzoic acid (Ch 55), suppress c-myc expression as all-trans-retinoic acid (RA) does. The decreased level of c-myc expression was detected within 5-14h after the start of treatment, and preceded morphological differentiation and functional differentiation measured in terms of nitroblue tetrazolium (NBT) reduction. Treatment of HL-60 cells with 0.1μM Am 80, Ch 55 or RA for 96h caused more than 90% suppression of c-myc expression and around 10-fold increase in the percentage of NBT-positive cells.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
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Kagechika Hiroyuki
Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat
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Kagechika Hiroyuki
Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.
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Kagechika Hiroyuki
Faculty Of Pharmaceutical Sciences University Of Tokyo
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SHUDO Koichi
Faculty of Pharmaceutical Sciences, The University of Tokyo
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Shudo Koichi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Shudo Koichi
Faculty Of Pharmaceutical Science Kyushu University
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KAWACHI Emiko
Faculty of Pharmaceutical Sciences, University of Tokyo
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HASHIMOTO YUICHI
Faculty of Pharmaceutical Sciences, University of Tokyo
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Shudo K
Research Foundation Itsuu Laboratory
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Kagechika H
Tokyo Medical And Dental Univ. Tokyo Jpn
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Kagechika Hiroyuki
Faculty Of Pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences The University Of Toky
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