ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS. SYNTHESIS AND ACTIVITY OF BENZOLACTAMS WITH ALKYL SUBSTITUENTS AT VARIOUS POSITIONS

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概要

• 論文の詳細を見る

• We synthesized benzolactams with hydrophobic substituents at various positions as analogs of (-)-benzolactam-V8-310 ((-)-BL-V8-310,1) which reproduces the active conformation and biological activity of teleocidins. Structure-activity data indicate that the existence of a hydrophobic region between C-2 and C-9,and the steric factor at C-8 play critical roles in the appearance of biological activities.

• 社団法人日本薬学会の論文
• 1997-02-15

著者

• 遠藤 泰之

  東北薬科大学薬学部

• ENDO Yasuyuki

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• SHUDO Koichi

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Shudo Koichi

  Faculty Of Pharmaceutical Science Kyushu University

• OHNO Michihiro

  Faculty of Pharmaceutical Sciences, University of Tokyo

• TAKEHANA Shunji

  Faculty of Pharmaceutical Sciences, University of Tokyo

• DRIEDGER Paul

  Procyon Pharmaceuticals, Inc.

• STABEL Silvia

  Max-Delbruck-Laboratorium

• Shudo K

  Research Foundation Itsuu Laboratory

• Driedger Paul

  Procyon Pharmaceuticals Inc.

• Ohno Michihiro

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Takehana Shunji

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Endo Yasuyuki

  Faculty Of Pharmaceutical Sciences Tohoku Pharmaceutical University

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