Functionalization of Polymethylcarboranes. Preparation and Reactivity of 2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic Acid

スポンサーリンク

概要

• 論文の詳細を見る

• The preparation and reactivity of poly-B-methyl-1,12-dicarba-closo-dodecaborane (poly-B-methyl-p-carborane) derivatives are described. 2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic acid was prepared from 2,3,4,5,6,7,8,9,10,11-decamethyl-1,12-decarba-closo-dodecaborane(12) by lithiation with methyllithium, followed by carboxylaiton. Conversion of the carboxylic acid into its ester and amide were achieved through its acyl chloride. The ester and the amide could not be hydrolyzed due to severe steric hindrance around the carbonyl group of the molecules owing to the adjacent B-methyl groups.

• 社団法人日本薬学会の論文
• 1999-05-15

著者

• 遠藤 泰之

  東北薬科大学薬学部

• YAMAGUCHI KENTARO

  Chemical Analytical Center, Chiba University

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• ENDO Yasuyuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• YAGUCHI Kyoko

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• TSUJI Motonori

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Shudo K

  Research Foundation Itsuu Laboratory

• Yamaguchi Kentaro

  Chemical Analysis Center Chiba University

• Yaguchi Kyoko

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

• Tsuji M

  Univ. Tokyo Tokyo Jpn

• Tsuji Motonori

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

• Endo Yasuyuki

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

• Yamaguchi Kentaro

  Chemical Analysis Center Chiba Univ. Chiba 263-8522 Jpn

関連論文

• 1-IV-1 新規non-seco-ステロイド型ビタミンD誘導体の創製(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
• A204 脱皮ホルモン活性物質に応答するレポータージーンアッセイの開発と新規殺虫剤クロマフェノジドの評価
• Enhancement of Human Papillomavirus Type 18 Gene Expression in HeLa Cells by 12-O-Tetradecanoylphorbol-13-acetate, 3β, 5α-Dihydroxycholestan-6-one, and Cholesterol
• Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbAlc Values(Analytical Biochemistry)
• Transvalencin A, a Thiazolidine Zinc Complex Antibiotic Produced by a Clinical Isolate of Nocardia transvalensis : II. Structure Elucidation
• ADVANCED COMPUTATIONAL DOCKING OF TWO TELEOCIDIN CONGENERS TO CYS2 DOMAIN OF PROTEIN KINASE Cδ
• TELEOCIDINS AND BENZOLACTAMS INHIBIT CELL KILLING BY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)
• 4.カルボラン含有ビタミンD誘導体の創製とVDR結合様式(第320回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
• カルボランの特性をいかしたアンドロゲン受容体リガンドの創製
• Grinding-Induced Equimolar Complex Formation between Thiourea and Ethenzamide
• Photocyclization of γ-chlorotiglyl-L-tryptophan Methyl Ester Yields Azocinoindole and Azepinoindole Derivatives
• Docking Study of Bryostatins to Protein Kinase Cδ Cys2 Domain
• Pd2 SUPERPOSITION OF TELEOCIDINS AND PHORBOL ESTERS BY A NEW COMPUTATIONAL METHOD
• Novel Channel Structure of Bile Acid-Guest Inclusion Complex Formed between Ursodeoxycholic Acid and Phenanthrene
• Crystal Structure of the Alcoholates and the Ansolvate of PNU-97018, an Angiotensin II Receptor Antagonist
• Collision-Induced Dissociation Actualized the H^+-Promoted Reaction as Observed in Vitro ; Harman Formation from β-Carboline-Type Monoterpenoid Glucoindole Alkaloids
• Dependence of Estrogenic Activity on the Shape of the 4-Alkyl Substituent in Simple Phenols
• Application of Difference NOE-pumping NMR Technique and Cold-Spray Ionization Mass Spectrometry to Identify a Ligand Binding with a Protein Receptor
• Facile Characterization of Polymer-Supported Reagents Using Cross Polarization Magic Angle Spinning Method in Solid State ^C-NMR
• Segment Identification of a Ligand Binding with a Protein Receptor Using Multidimensional T_1ρ-, Diffusion-Filtered and Diffusion-Ordered NOESY Experiments
• A New Broad Band Probe Covering from ^P-to^Cl-Nuclear Magnetic Resonance
• PFG J-HMBC 2D NMR Spectroscopic Observation of the Natural Abundance ^1H-^N Long-Range Coupling
• (Cis)-PREFERENCE OF N, N'-DIMETHYL-N, N'-DIPHENYLGUANIDINE AND THE GUANIDINIUM SALT. CONSTRUCTION OF WATER-SOLUBLE AROMATIC LAYERED STRUCTURE
• STERICAL PRORERTIES OF N, N'-DIMETHYLUREA MOIETY ENHANCE FORMATION OF TRIPLY HYDROGEN-BONDED COMPLEXES
• ホウ素クラスター : カルボランの有機化学 : 合成, 構造, 立体分子構築への応用
• 創薬化学における新規3次元的疎水性構造単位の開発と応用(最前線,ポストゲノム時代の有機化学)
• ヘクソカズラの果実の成分研究 : 新規イリドイドPaederia lactoneの構造
• ホウ素クラスターの医薬化学への応用
• 70(P-55) γ-置換ブテノリドを活用する天然物のエナンチオ制御合成(ポスター発表の部)
• ビニルおよびアリル置換キラルブテノリド類のエナンチオ制御合成
• Enhancing Effect of Tumor Promoters, Phorbol Esters and Teleocidins on Nuclear Receptor-Mediated Transcription
• Identification of Protein Disulfide Isomerase as a Phorbol Ester-Binding Protein
• New Estrogenic Antagonists Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore
• Functionalization of Polymethylcarboranes. Preparation and Reactivity of 2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic Acid
• Dicarba-closo-dodecaboranes as a Pharmacophore. Novel Potent Retinoidal Agonists
• Dicarba-closo-dodecaboranes as a Pharmacophore. Retinoidal Antagonists and Potential Agonists
• 生理活性化合物としてのホウ素クラスター--医薬品への応用をめざして
• 3β, 5α-DIHYDROXYCHOLESTAN-6-ONE EXISTS IN HUMAN BLOOD
• ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS. SYNTHESIS AND ACTIVITY OF BENZOLACTAMS WITH ALKYL SUBSTITUENTS AT VARIOUS POSITIONS
• Photoaffinity Labeling of Tumor Promoter-Binding Protein (CN-TPBP) and Preparation of Affinity Sorbent Gels
• ROLE OF THE HYDROPHOBIC MOIETY OF TUMOR PROMOTERS. SYNTHESIS AND ACTIVITY OF 9-ALKYLATED BENZOLACTAMS
• 発がんプロモーターの活性立体構造の解析
• Deletion Mutants of Human Deoxycytidine Kinase mRNA in Cells Resistant to Antitumor Cytosine Nucleosides
• Isolation of Deoxycytidine Kinase from Ehrlich Carcinoma Cells by Affinity Chromatography Based on a Substrate Analog, 2'-C-Cyano-2'-deoxy-1-β-D-arabinofuranosyl-N^4-palmitoylcytosine
• α-Glucosidase Inhibitors with a 4, 5, 6, 7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or Dicarba-closo-dodecaborane Group
• Modulators of Tumor Necrosis Factor α Production Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore
• Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids
• NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY
• POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON
• Polyenylidine Thiazolidine Derivatives with Retinoidal Activities
• Photoaffinity Labeling of the Ligand-Interacting Helix of the Retinoic Acid Receptor Alpha
• Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4
• NOVEL AROMATIC UREA DERIVATIVES WITH DNA-BINDING ABILITY
• DEIODOTRIFLUOROMETHYLATION OF ETHYL 3,3', 5-TRIIODOTHYROACETATE. DIVERGENT DERIVATIZATION BASED ON THE COMBINATORIAL CONCEPT
• New-Type Inducers of Differentiation of HL-60 Leukemia Cells Suppress c-myc Expression(Medeicinal Chemistry,Chemical)
• 8 テレオシジン類の活性立体構造の決定 : 立体配座固定化合物の合成と生物活性(口頭発表の部)
• Crystal Structures and Physical Properties of Tris-(2, 3-epoxypropyl)-isocyanate
• Design and synthesis of novel retinoid synergists having a dibenzodiazepine skeleton
• A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm(Communications to the Editor)
• Anicequol, a Novel Inhibitor for Anchorage-independent Growth of Tumor Cells from Penicillium aurantiogriseum Dierckx TP-F0213
• 1.カルボランの脂溶性ファーマコフォアとしての特性 : 核内ビタミンD_3受容体リガンドへの応用(脂溶性ビタミン総合研究委員会 第303回会議研究発表要旨)
• 3.カルホラン含有レチノイト(第300回脂溶性ビタミン総合研究委員会研究発表要旨)
• Structural Identification of a Major Cytokinin in Coconut Milk as 14-O-{3-O-[β-D-Galactopyranosyl-(1→2)-α-D-galactopyranosyl-(1→3)-α-L-arabinofuranosyl]-4-O-(α-L-arabinofuranosyl)-β-D-galactopyranosyl}trans-zeatin Riboside
• Novel Channel Structure Formed with Methyl 3-(9-Anthrylcarbonyloxy)cholate Using Orthogonally Stacked Building Blocks
• Cellular localization and functional characterization of the equilibrative nucleoside transporters of antitumor nucleosides
• Electrospray Ionization Mass Spectrometric Observation of the Coordinative Interaction of α, β-Unsaturated Ketones with Cerium (III) Cation
• Synthesis of Oxygenated Cholesterols as Structural Mimics of Phorbol Ester-Type Tumor Promoters
• Synthesis, Conformation, and Chemical Properties of New Mini Parallel Double-Stranded Peptides Conjugated with -Phe-Phe- and -Phe-Phe-X- Sequences
• Location of Two Photoaffinity-Labeled Sites on the Ligand-Binding Domain of Retinoic Acid Receptor α
• フェノキセニウムイオンの生成と反応
• テレオシジンの活性立体配座 : 新規活性分子のデザインと合成
• ANIONIC HETERO[3,3]REARRANGEMENTS. N, O-DIACYLHYDROXYLAMINES TO SUCCINIC ACID DERIVATIVES
• Synthesis of 1-Stibaphenalenes, the First Example of Group 15 Phenalenes, via a 1,5-Dilithium Intermediate
• Twist Form of Teleocidin Derivatives is Active in in Vivo Tumor Promotion by (-)-Benzolactam-V8-310
• A new chiral synthesis of a bicyclic enedione containing a seven-membered ring mediated by a combination of chiral amine and bronsted acid
• Enantioselective Intramolecular Aldol Reaction Mediated by a Combination of L-Amino Acid and Bronsted Acid to Construct a Bicyclic Enedione Containing a 7-Membered Ring
• ASYMMETRIC ADDITIONS OF ALKYLLITHIUM TO CHIRAL IMINES : α-HAPHTHYLETHYL GROUP AS A CHIRAL AUXILIARY
• Absolute Configuration of Cathine
• Complementary Multicomplexation of Desymmetrized 2, 2'-Bipyridine Ligands on Square Planar Pd(II) Centers
• Stabilization of a Self-assembled Coordination Nanotube by Covalent Link
• A Chiral M_6L_4 Cage Complex Assembled from a D_-Symmetric Ligand: Self-Assembly, Structure, and Chirality Observation
• Design Optimization of Surgical Drills Using the Taguchi Method
• Stereoselective Synthesis of 4'-α-Alkylcarbovir Derivatives Based on an Asymmetric Synthesis or Chemoenzymatic Procedure
• A SEC-HPLC-ICP MS hyphenated technique for identification of sulfur-containing arsenic metabolites in biological samples
• Molecular Structure of Bromophenol Blue Having a γ-Sultone Ring
• SEPARATION OF A HIGH-AFFINITY CYTOKININ-SPECIFIC BINDING PROTEIN (CSBP) BY SPECIFIC AFFINITYCHROMATOGRAPHY
• Single Crystal X-Ray Analyses of a Series of Hexamethylphosphoramide-Coordinated Complexes of Rare Earth Triflates : Existence of Tetrad Effects in the Coordinate Bonds
• Preparation and Properties of Hexamethylphosphoramide-Coordinated Complexes of Samarium(III) Iodide
• Internal Calibrant for an Exact Mass Measurement in Electrospray Ionization Mass Spectrometry

もっと見る 閉じる

スポンサーリンク