Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4

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概要

• 論文の詳細を見る

• Retinoids, including all-trans-retinoic acid (ATRA), its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. Binding activity of typical retinoids to nuclear retinoic acid receptors (RARs) was also investigated. A good linear correlation between the ED_<50> values of differentiation-inducing activity towards HL-60 cells and those towards NB4 cells was found. Binding activities of retinoids to RARα and RARβ also correlated well to the differentiation-inducing activities.

• 公益社団法人日本薬学会の論文
• 1996-10-15

著者

• FUKASAWA Hiroshi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• Kagechika Hiroyuki

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• SHUDO Koichi

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Shudo Koichi

  Faculty Of Pharmaceutical Science Kyushu University

• FUKASAWA Hiroshi

  Faculty of Pharmaceutical Sciences, University of Tokyo

• KAWACHI Emiko

  Faculty of Pharmaceutical Sciences, University of Tokyo

• SAITO Go

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Shudo K

  Research Foundation Itsuu Laboratory

• Fukasawa Hiroshi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Saito Go

  Faculty Of Engineering Gunma University

• Saito Go

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Fukasawa H

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Kagechika Hiroyuki

  Faculty Of Pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences The University Of Toky

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