NOVEL AROMATIC UREA DERIVATIVES WITH DNA-BINDING ABILITY

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概要

• 論文の詳細を見る

• Several aromatic urea derivatives were designed and synthesized as DNA-targeting agents. N, N'-Dimethyl-N, N'-bis[(4-amidylphenyl)amino-carbonyl]-2,6-diaminopyridine (1) and 1,3-bis[5-(glycylamino)pyrid-2-yl]urea (3) showed remarkable DNA-binding abilities as determined by ultrafiltration assay using calf thymus DNA, their potencies being equal to and half that of netropsin, respectively. Compound 1 inhibited the proliferation of both L1210 cells and KB cells with similar IC_<50> values to netropsin.

• 公益社団法人日本薬学会の論文
• 1996-10-15

著者

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• Kagechika Hiroyuki

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• SHUDO Koichi

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Shudo Koichi

  Faculty Of Pharmaceutical Science Kyushu University

• FUKUTOMI Ryuuta

  Faculty of Pharmaceutical Sciences, University of Tokyo

• Shudo K

  Research Foundation Itsuu Laboratory

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Kagechika Hiroyuki

  Faculty Of Pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences The University Of Toky

• Fukutomi Ryuuta

  Faculty Of Pharmaceutical Sciences University Of Tokyo:nisshin Flour Milling Co. Ltd.

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