NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY

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概要

• 論文の詳細を見る

• Several arylmethylidene thiaxolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).

• 公益社団法人日本薬学会の論文
• 1998-05-15

著者

• ITAI Akiko

  Institute of Medicinal Molecular Design, Inc

• FUKASAWA Hiroshi

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• KAGECHIKA Hiroyuki

  Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• Itai Akiko

  Insitute Of Medicinal Molecular Design Key Molecular Inc.

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Shudo Koichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• KAWACHI Emiko

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• RBISAWA Masayuki

  Graduate School of Pharmaceutical Sciences, University of Tokyo

• Shudo K

  Research Foundation Itsuu Laboratory

• Itai Akiko

  Institute Of Medicinal Molecular Design

• Ebisawa Masayuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Fukasawa Hiroshi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Fukasawa H

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Rbisawa Masayuki

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

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