Thiazolidinediones with Thyroid Hormone Receptor Agonistic Activity
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概要
- 論文の詳細を見る
Several thiazolidinedione derivatives (3-7) were designed and synthesized as candidate thyromimetic drugs. Among them, the dihydrogenated compounds, such as 5-2-[[4-(3-tert-butyl-4-hydroxyphenyl)oxy-3,5-diiodophenyl]ethyl]-2,4-thiazolidine-dione (6d) and its 3-isopropyl analog (7b), exhibited potent thyroid hormone receptor α1 (TRα1) activation activity.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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FUKASAWA Hiroshi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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KAGECHIKA Hiroyuki
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Kagechika Hiroyuki
Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat
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Kagechika Hiroyuki
Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.
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Inoue Noriko
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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EBISAWA Masayuki
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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SOTOME Tomomi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Ebisawa Masayuki
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Fukasawa Hiroshi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Kobayashi Hisayoshi
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Inoue Natsu
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Sotome Tomomi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Fukasawa H
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Kagechika H
Tokyo Medical And Dental Univ. Tokyo Jpn
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