Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton

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概要

• 論文の詳細を見る

• We synthesized a series of compounds based on the potent tubulin-polymerization inhibitor 5-hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [5HPP-33 (3)], which is structurally derived from thalidomide (1), and investigated their inhibitory effects on tubulin polymerization. Direct interaction between 5HPP-33 (3) and α,β-tubulin heterodimer protein was demonstrated by means of a surface plasmon resonance study.

• 公益社団法人日本薬学会の論文
• 2007-06-01

著者

• Aoyama Hiroshi

  東京大学分子細胞生物学研究所

• Aoyama Hiroshi

  Univ. Tokyo Tokyo Jpn

• Aoyama Hiroshi

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• Nakamura Takanori

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• KOBAYASHI Hisayoshi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• MIYACHI Hiroyuki

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Kobayashi H

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Univ. Tokyo Tokyo Jpn

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• 中山 太ニ

  岡山大学薬学部薬剤学教室

• MISAWA Takashi

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• NOGUCHI Tomomi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Miyachi Hiroyuki

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular And Cellular Biosciences The Universityv Of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Misawa Takashi

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Noguchi T

  Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.

• Miyachi H

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Miyachi Hiroyuki

  Div. Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Noguchi-yachide Tomomi

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

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