Modification by Heme Oxygenase Inhibitor, Tin Protoporphyrin, of Cellular Differentiation of Human Myeloid Leukemia K562 Cell Line

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概要

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• Human myeloid leukemia K562 cells can be induced to differentiate to mature cells bidirectionally, i.e., hemin induces erythroid differentiation, while 12-O-tetradecanoylphorbol 13-acetate (TPA) induces differentiation to monocytes. TPA is also a potent inducer of heme oxygenase (HO), which catabolizes heme to biliverdin. We show here that TPA suppresses hemin-induced erythroid differentiation of K562 cells, while retinoids augment it. Further, an HO inhibitor, tin protoporphyrin (SnPP), suppresses TPA-induced K562 cell differentiation to monocytes. It was also found that co-treatment of K562 cells with SnPP and TPA induces erythroid differentiation of K562 cells, though SnPP alone or TPA alone does not induce erythroid differentiation, suggesting a role of HO in the directional switch of differentiation.

• 公益社団法人日本薬学会の論文
• 1999-04-15

著者

• 藤本 康弘

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 小磯 邦子

  東大分生研

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Nakajima O

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• KOISO Yukiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• FUJIMOTO Yasuyuki

  Institute of Molecular and Cellular Biosciences University of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Fujimoto Y

  Department Of Biochemistry Hokkaido College Of Pharmacy

• MATSUMURA Daisuke

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• NAKAJIMA Osamu

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Matsumura Daisuke

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Nakajima Osamu

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

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