EFFECT OF CYP2C POLYMORPHISMS ON THE PHARMACOKINETICS OF PHENYTOIN IN JAPANESE PATIENTS WITH EPILEPSY
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effect of CYP2C9/19 polymorphisms on the pharmacokinetics of phenytoin in 17 Japanese patients with epilepsy. The maximal elimination rate (V_<max>) of phenytoin was slightly decreased (up to 14%) in patients with CYP2C19 mutations for the defective allele. The V_<max> values in patients with a CYP2C9 mutation for the heterozygous Ile/Leu^<359> allele were 40% lower than those in patients with wild-type CYP2C9 for the homozygous Ile^<359> allele. These findings suggested that the genetic polymorphism of CYP2C isoenzymes plays an important role in the pharmacokinetic variability of phenytoin, and that the mutation in CYP2C9 proteins is a determinant of impaired metabolism of the drug.
- 社団法人日本薬学会の論文
- 1996-08-15
著者
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INUI Ken-ichi
Department of Pharmacy, Kyoto University Hospital
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TAKANO Mikihisa
Department of Pharmaceutics and Therapeutics, Division of Clinical Pharmaceutical Science, Programs
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HATTORI Haruo
Department of Pediatrics, Kyoto University Faculty of Medicine
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Takano M
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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HASHIMOTO Yukiya
Department of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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OTSUKI Yuko
Department of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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ODANI Atsuko
Department of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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FURUSHO Kenshi
Department of Pediatrics, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Hattori Haruo
Department Of Pediatrics Faculty Of Medicine Kyoto University
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Hattori Haruo
Department Of Pediatrics Kyoto University Hospital Faculty Of Medicine Kyoto University
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Takano M
Tohoku Pharmaceutical University
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鷹野 正興
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Hashimoto Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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松井 貴史
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takano M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences And High Technology Research Center
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Furusho Kenshi
Department Of Pediatrics Faculty Of Medicine Kyoto University Japan
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Furusho Kenshi
Department Of Pediatrics Kyoto University Hospital Faculty Of Medicine Kyoto University
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Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University
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Otsuki Yuko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Hashimoto Yukiya
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Hashimoto Yukiya
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Inui Ken‐ichi
Kyoto Univ. Hospital Kyoto Jpn
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Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University Hospital Kyoto University
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Hashimoto Y
Institute Of Molecular & Cellular Biosciences The University Of Tokyo
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Takano Mikihisa
Department Of Pharmaceutics And Therapeutics Graduate School Of Biomedical Sciences Hiroshima Univer
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Inui Ken-ichi
Department of Hospital Pharmacy, School of Medicine, Tokyo Medical and Dental College
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