Evaluation of Calvert's Formula for Dosage Adjustment of Carboplatin in Japanese Patients with Hormone Refractory Prostate Cancer(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
For hormone refractory prostate carcinoma, a combination therapy of paclitaxel and carboplatin is used to expect life extention. We investigated the pharmacokinetics of carboplatin in Japanese prostate cancer patients (n=10, 55-72 years), and evaluated the usefulness of Calvert's formula in the individualized dosing adjustment. They were intravenously administered carboplatin (area under the free plasma concentration versus time curve (AUC)=5mg・min/ml), following the intravenous administration of paclitaxel (175mg/m^2). The dosage of carboplatin for each patient was determined with Calvert's formula using individual creatinine clearance values. Plasma concentration of total platinum was measured sequentially and the pharmacokinetic parameters of carboplatin were determined in each patient. Plasma concentration of total carboplatin after intravenous infusion well fitted the two-compartment model. Carboplatin clearance was 62.0±12.7ml/min (mean±S.D.), and linearly related to the individual creatinine clearance (r^2=0.64, p<0.01). The actual AUC for total carboplatin was 8.20±1.11mg・min/ml, and its inter-individual variability was decreased to 65% of that in carboplatin clearance, indicating the effectiveness of Calvert's formula for dosage adjustment of carboplatin. Leucopenia of grade 4 according to the National Cancer Institute's Common Toxicity Criteria was found in one patient, but no patient demonstrated thrombocytopenia. In conclusion, determining carboplatin dosage based on Calvert's formula decreased the inter-individual variability in the actual AUC compared with that in the carboplatin clearance, and a target AUC of 5mg・min/ml of carboplatin was comparatively safe for Japanese patients with prostate cancer.
- 社団法人日本薬学会の論文
- 2006-07-01
著者
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Ogawa O
Department Of Urology Kyoto University Graduate School Of Medicine
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Ogawa Osamu
京都大学 医学研究科泌尿器科学
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MASUDA Satohiro
Department of Pharmacy, Kyoto University Hospital
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INUI Ken-ichi
Department of Pharmacy, Kyoto University Hospital
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OGAWA OSAMU
Department of Urology, Faculty of Medicine, Kyoto University
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NISHIYAMA HIROYUKI
Departments of Urology, Kyoto University Graduate School of Medicine
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SEGAWA TAKEHIKO
Departments of Urology, Kyoto University Graduate School of Medicine
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ITO NORIYUKI
Departments of Urology, Kyoto University Graduate School of Medicine
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KAMOTO TOSHIYUKI
Departments of Urology, Kyoto University Graduate School of Medicine
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Satoh Takefumi
北里大学 医学部泌尿器科学
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Katsura Toshiya
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Suyama Takahito
Department Of Urology Graduate School Of Medicine Chiba University
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MOTOHASHI Hideyuki
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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TAKAHASHI Kazushige
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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YANO Ikuko
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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JIKO Mari
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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SATO Eriko
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Sato Eriko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Kamoto T
Department Of Urology Kyoto University Graduate School Of Medicine
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Nishiyama Hiroyuki
Department Of Urology Kyoto University Hospital
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Kamba Tomomi
Department Of Urology Kyoto University Hospital Faculty Of Medicine Kyoto University
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Kamoto Toshiyuki
Department Of Pathology And Biology Of Diseases Graduate School Of Medicine Kyoto University
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Sakamoto Masato
Department Of Radiation Oncology And Image-applied Therapy Graduate School Of Medicine Kyoto Univers
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Takahashi Kazushige
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Saika Takashi
川崎医科大学 泌尿器科学
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Kotake Toshihiko
Department Of Urology Osaka Medical Center For Cancer And Cardiovascular Diseases
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Nishiyama Hiroyuki
Department Of Clinical Molecular Biology Faculty Of Medicine Kyoto University
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Jiko Mari
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Yano Ikuko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Yano Ikuko
Department Of Clinical Pharmacy And Education Graduate School Of Pharmaceutical Sciences Kyoto Unive
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Ito Noriyuki
Department Of Urology Graduate School Of Medicine Kyoto University
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Ito Noriyuki
Department Of Mechanical Engineering Shibaura Institute Of Technology
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SHITARA TOSHIYA
Fuchinobe General Hospital
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Hashida Tohru
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University
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Saka Toshihisa
Department Of Urology Nara Medical University
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Inui Ken‐ichi
Kyoto Univ. Hospital Kyoto Jpn
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Takahashi Kazushige
National Cancer Center
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Tatarano Shuichi
Department Of Urology Graduate School Of Medical And Dental Sciences Kagoshima University
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Motohashi Hideyuki
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Motohashi Hideyuki
Department Of Pharmacy Kyoto University Hospital
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Segawa Takehiko
Department Of Urology Graduate School Of Medicine Kyoto University
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Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University Hospital Kyoto University
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Masuda Satohiro
Department Of Radiation Oncology And Image-applied Therapy Kyoto University Graduate School Of Medic
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Masuda Satohiro
Department Of Pharmacy Kyoto University Hospital
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Kamba Tomomi
Department Of Urology Kyoto University Graduate School Of Medicine
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Ogawa Osamu
Department Of Urology Faculty Of Medicine Kyoto University
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Sato Eriko
Department Of Hematology Juntendo University School Of Medicine
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Katsura Toshiya
Department Of Urology Kyoto University Graduate School Of Medicine Kyoto University
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Ogawa Osamu
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Katsura Toshiya
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine
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Motohashi Hideyuki
Department Of Bioproduction Technology Junior College Of Tokyo University Of Agriculture
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Kano Ikuko
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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INUI Kenichi
Department of Pharmacy, Faculty of Medicine, Kyoto University Hospital, Kyoto University
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Inui Ken-ichi
Department of Hospital Pharmacy, School of Medicine, Tokyo Medical and Dental College
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Masuda Satohiro
Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital
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Ogawa Osamu
Department of Cardiology, Niigata Prefectural Central Hospital, Japan
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Sato Eriko
Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University
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