Hepatic Extraction of Tacrolimus in Rats with Experimental Liver Diseases
スポンサーリンク
概要
- 論文の詳細を見る
Tacrolimus, an immunosuppressive agent, is metabolized mainly in the liver and has shown large intra- and interindividual pharmacokinetic variability. We investigated the effect of liver dysfunctions on the pharmacokinetics of tacrolimus in rats with experimental liver diseases. Experimental hepatic failure was induced by CCl_4-treatment or bile duct ligation. Tacrolimus (1 or 0.3 mg/kg) was administered intravenously or intraportally to the rats (n=5-6 per group), and blood samples were collected over a 240-min period. The tacrolimus concentrations in the blood were then measured by a high-performance liquid chromatography-enzyme immunoassay. In the normal rats, the hepatic extraction ratio of tacrolimus (E_H) was dose-independent, ranging from 0.566-0.598 at 0.3 and 1.0 mg/kg doses. The E_H were dose-dependent in the CCl_4-treated rats and in the bile duct-ligated rats : the E_H at 1.0 mg/kg dose were 0.158-0.170 and those at 0.3 mg/kg dose were 0.329-0.394. The intermediate E_H of tacrolimus suggested that the clearance of tacrolimus depends not only on hepatic intrinsic clearance but also on hepatic blood flow. The present pharmacokinetic study also suggested that the decrease of E_H and the dose-dependence of E_H contribute to the elevation of blood tacrolimus concentrations and to the large variability in the pharmacokinetics of tacrolimus after oral administration in hepatic dysfunctions.
- 公益社団法人日本薬学会の論文
- 1998-06-15
著者
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INUI Ken-ichi
Department of Pharmacy, Kyoto University Hospital
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HASHIMOTO Yukiya
Department of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Shimizu Takako
Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama
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Shimizu Takako
Department Of Oral Surgery Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama
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Shimizu Takako
Department Of Internal Medicine Nihon University School Of Medicine
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Shimizu Takako
Graduate School Of Pharmaceutical Sciences University Of Toyama
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Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University
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Hashimoto Yukiya
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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SASA Hiroaki
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Sasa Hiroaki
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Inui Ken-ichi
Department of Hospital Pharmacy, School of Medicine, Tokyo Medical and Dental College
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