DIFFERENCES IN EFFECTS ON DRUG ABSORPTION BETWEEN DIHYDROXY AND TRIHYDROXY BILE SALTS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of a dihydroxy bile salt, sodium taurodeoxycholate (STDC), on drug absorption from rat small intestine was investigated in comparison with that of trihydroxy one, sodium cholate (STC). The enhancement or inhibitory effects on the absorption of various model drugs by STDC bore similar tendency to those by STC, and the magnitude was greater than the latter. The absorption of sulfaguanidine was enhanced by STDC, which solubilized the phospholipids from the mucosal barrier membrane in addition to the STC-like, or ethylenediaminetetraacetate-like action. STDC inhibited the absorption of sulfadimethoxine contrary to the insignificant effect by STC. The direct action of STDC on the mucosal membrane reduced the absorption in addition to the physicochemical action, such as micellar complex formation. Quinine absorption was inhibited in the presence of STDC, which can be explained by the micellar complex formation. Possible mechanisms of the differences in the effect of STDC and STC were discussed in relation to their micellar properties.
- 公益社団法人日本薬学会の論文
著者
-
Sezaki Hitoshi
Faculty Of Pharmaceutical Sciences Kyoto University
-
Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
-
Inui Ken-ichi
Department Of Pharmacy Kyoto University Hospital
-
Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University
関連論文
- 成人生体肝移植症例において, ラベプラゾールの併用はタクロリムスの血中濃度推移に影響を及ぼさない
- Biliary Excretion of Mitomycin C Dextran Conjugates in Relation of Physicochemical Characteristics of Carrier Dextran
- UGT1A1^*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients
- EFFECT OF CYP2C POLYMORPHISMS ON THE PHARMACOKINETICS OF PHENYTOIN IN JAPANESE PATIENTS WITH EPILEPSY
- Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney
- Distinct Effects of Omeprazole and Rabeprazole on the Tacrolimus Blood Concentration in a Kidney Transplant Recipient
- Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers
- Evaluation of Calvert's Formula for Dosage Adjustment of Carboplatin in Japanese Patients with Hormone Refractory Prostate Cancer(Biopharmacy)
- Surgical resection deteriorates gemcitabine-induced leukopenia in pancreatic cancer
- EFFECT OF MEDIUM-CHAIN GLYCERIDES (MGK^[○!R]) ON THE INTESTINAL ABSORPTION AND THE HEPATOBILIARY TRANSPORT OF BROMTHYMOL BLUE
- STUDY ON THE ACTION OF PERCUTANEOUS PENETRATION ENHANCERS : EFFECT ON VARIOUS DRUGS WITH DIFFERENT PHYSICOCHEMICAL PROPERTIES
- Analysis of Drug Penetration through Skin Considering Donor Concentration Decrease
- EFFECTS OF MITOMYCIN C, 5-FLUOROURACIL AND CYCLOPHOSPHAMIDE ON DRUG ABSORPTION, ENZYME ACTIVITIES AND MUCOSAL LIPID COMPOSITION OF INTESTINE
- A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel : An Initial Report of the Phase I-IIa Study
- ラットにおけるペプチドトランスポータを介するβ-ラクタム抗生物質セフチブテンの吸収に及ぼす亜鉛の阻害効果
- Temporal Decline in Sirolimus Elimination Immediately After Pancreatic Islet Transplantation
- Delayed Effect of Grapefruit Juice on Pharmacokinetics and Pharmacodynamics of Tacrolimus in a Living-Donor Liver Transplant Recipient
- 腎上皮細胞におけるクレアチニンの経細胞輸送
- Required Transient Dose Escalation of Tacrolimus in Living-Donor Liver Transplant Recipients with High Concentrations of a Minor Metabolite M-II in Bile
- Interaction between Tacrolimus and Lansoprazole, but not Rabeprazole in Living-Donor Liver Transplant Patients with Defects of CYP2C19 and CYP3A5
- Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
- TRANSPORT CHARACTERISTICS OF p-ACETAMIDOBENZOIC ACID IN BRUSH BORDER MEMBRANE OF RAT SMALL INTESTINE
- EFFECT OF SURFACTANTS ON THE ABSORPTION OF p-AMINOBENZOIC ACID FROM THE RAT INTESTINE
- COMPARATIVE STUDIES ON THE ABSORPTION MECHANISM OF p-AMINOBENZOIC ACID AND p-ACETAMIDOBENZOIC ACID FROM THE RAT INTESTINE
- ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT SMALL INTESTINE IN SITU
- ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT INTESTINE IN VITRO
- TRANSPORT CHARACTERISTICS AND CYTOTOXICITY OF CYCLOSPORIN A IN CULTURED KIDNEY EPITHELIAL CELL LINE (LLC-PK_1)
- Factors Determining Drug Residence in Skin during Transdermal Absorption : Studies on β-Blocking Agents
- EVALUATION OF DRUG DISPOSITION IN BRAIN BY MOMENT ANALYSIS (II)
- ELECTROPHYSIOLOGICAL INVERSTIGATIONS ON THE DRUG PERMEATION ACROSS STRATUM CORNEUM (I)
- Effects of Sodium or Glucose Exclusion from the Incubation Medium on Drug Transfer across Rat Jejunal Membrane in Vitro : An Electrophysiological Study(Pharmaceutical)
- EFFECTS OF ABSORPTION PROMOTERS ON THE SELECTIVE PERMEABILITY OF RAT INTESTINAL MEMBRANE TO IONS : ANALYSIS OF PERMEABILITY ENHANCING MECHANISMS BY USING DIFFUSION POTENTIALS
- INVESTIGATIONS OF INFLUX AND ACCUMULATION PROCESSES OF β-LACTAM ANTIBIOTICS AND THEIR ROLE IN THE TRANSMURAL TRANSFER ACROSS RAT JEJUNUM
- FURTHER INVESTIGATIONS ON THE TRANSPORT MECHANISM OF CEPHALEXIN AND AMPICILLIN ACROSS RAT JEJUNUM
- ELECTROPHYSIOLOGICAL APPROACH TO THE ACTION OF TAURINE ON RAT GASTRIC MUCOSA
- New Methods to Evaluate Intestinal Drug Absorption Mediated by Oligopeptide Transporter from In vitro Study using Caco-2 Cells
- Quantitative Evaluation of the Gastrointestinal Absorption of Protein into the Blood and Lymph Circulation
- Methotrexate-Loxoprofen Interaction : Involvement of Human Organic Anion Transporters hOAT1 and hOAT3
- Common single nucleotide polymorphisms of the MDR1 gene have on influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients
- Decreased Function of Genetic Variants, Pro283Leu and Arg287Gly, in Human Organic Cation Transporter hOCT1
- ANALYSIS OF ACTION MECHANISM OF PERCUTANEOUS PENETRATION ENHANCER BASED ON PHYSIOLOGICAL SKIN DIFFUSION MODEL
- Cellular and Molecular Mechanisms of Renal Tubular Secretion of Organic Anions and Cations
- IMMUNOLOGICAL CONTROL OF DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT : EFFECT OF LOCAL ANAPHYLAXIS ON THE INTESTINAL ABSORPTION OF LOW MOLECULAR WEIGHT DRUGS IN THE RAT
- EFFECT OF SYNTHETIC SURFACTANTS ON DRUG ABSORPTION IN THE PRESENCE OF A PHYSIOLOGIC SURFACTANT, SODIUM TAUROCHOLATE, IN RATS
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS. II
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS.I
- AN ASSESSMENT OF GASTRIC ULCERS IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN RATS
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : EFFECT OF ANAPHYLAXIS ON THE ABSORPTION OF SALICYLIC ACID FROM THE RAT SMALL INTESTINE
- タクロリムス併用の膵島移植患者では, 同一血中濃度に維持するためにシロリムスに比べてエベロリムスでより多くの投与量を必要とする
- hOCT2を介したクレアチニン輸送に対するキノロン系抗菌薬DX-619及びレボフロキサシンの相互作用
- QUANTITATIVE ANALYSIS OF DRUG DISPOSITION : APPLICATION OF STATISTICAL MOMENT THEORY TO LOCAL PERFUSION SYSTEM
- CONTROL OF IN VIVO FATE OF PROTEIN DRUGS USING CHEMICAL MODIFICATION WITH SUGARS
- Design and Evaluation of Monoclonal Antibody-Antitumor Agent Conjugate
- EFFECT OF TEMPERATURE ON INTESTINAL TRANSFER AND TISSUE UPTAKE OF SULFANILAMIDE AND AMINOPROPYRON IN VITRO
- CELLULAR INTERACTION AND ANTITUMOR ACTIVITY OF MITOMYCIN C PRODRUGS
- URINARY EXCRETION CHARACTERISTICS OF A POLYMERIC PRODRUG OF MITOMYCIN C, MITOMYCIN C-DEXTRAN CONJUGATE
- ENHANCED LYMPHATIC DELIVERY OF MIYOMYCIN C BY POLYMERIC MODIFICATION
- EFFECT OF TAURINE ON THE GASTRIC ABSORPTION OF DRUGS : COMPARATIVE STUDIES WITH SODIUM LAURYL SULFATE
- EFFECT OF TAURINE ON THE GASTROINTESTINAL ABSORPTION OF DRUGS-IONIC REQUIREMENT FOR THE ACTION
- SODIUM ION-DEPENDENCY OF TAURINE-INDUCED ENHANCEMENT OF DRUG ABSORPTION FROM RAT STOMACH IN SITU
- MECHANISM OF THE ABSORPTION OF WATER-SOLUBLE DRUGS FROM THE GASTROINTESTINAL TRACT : ABSORPTION OF β-LACTAM ANTIBIOTICS FROM RAT SMALL INTESTINE
- CARRIER-MEDIATED TRANSPORT SYSTEMS FOR AMINOPENICIL-LINS IN RAT SMALL INTESTINE
- PREPARATION AND BIOPHARMACEUTICAL EVALUATION OF MICROCAPSULES : AMOXICILLIN AND PIRETANIDE
- CHARACTERIZATION OF AMINOCEPHALOSPORIN TRANSPORT ACROSS RAT SMALL INTESTINE
- EFFECT OF TAURINE ON DRUG ABSORPTION FROM THE RAT GASTROINTESTINAL TRACT
- Application of Propranolol to the Keratinized Oral Mucosa : Avoidance of First-Pass Elimination and the Use of 1-Dodecylazacycloheptan-2-one (Azone) as an Absorption Enhancer of Bioadhesive Film-Dosage Form
- Involvement of Specific Transport System of Renal Basolateral Membranes in Distribution of Nicotine in Rats
- EFFECT OF COMPLEXATION WITH DEXTRAN SULFATE ON THE LYMPHATIC DELIVERY OF BLEOMYCIN FOLLOWING INTRASTITIAL ADMINISTRATION
- PHARMACEUTICAL STUDIES ON LIPOSOMES : IMPROVEMENT OF ENTRAPPING EFFICIENCY FOR WATER SOLUBLE DRUGS BY FREEZING METHOD
- Hepatic Extraction of Tacrolimus in Rats with Experimental Liver Diseases
- DISPOSITION OF SECRETIN IN RAT STOMACH AND PANCREAS
- Intestinal Absorption of Drugs Mediated by Drug Transporters: Mechanisms and Regulation
- Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine
- Decreased Renal Accumulation and Toxicity of a New VCM Formulation in Rats with Chronic Renal Failure
- GENTAMICIN BINDING TO BRUSH BORDER AND BASOLATERAL MEMBRANES ISOLATED FROM RAT KIDNEY CORTEX
- Drug transporters and their application to personalized medicine
- A Retrospective Analysis of Vancomycin Pharmacokinetics in Japanese Cancer and Non-cancer Patients Based on Routine Trough Monitoring Data(Biopharmacy)
- ANTITUMOR ACTIVITY OF LIPOPHILIC PRODRUGS OF MITOMYCIN C ENTRAPPED IN LIPOSOME OR O/W EMULSION
- DEVELOPMENT OF LIPOPHILIC MITOMYCIN C PRODRUGS AND THEIR APPLICATION TO LIPID DISPERSION SYSTEMS
- EXPERIMENTAL ANALYSIS OF ANOMALOUS DISPOSITIONS IN DISEASE STATES : DRUG PHARMACOKINETICS IN RATS WITH HEPATIC DISEASES
- Pharmacokinetics of Cefpiramide in Rats Acutely Intoxicated with Carbon Tetrachloride
- Pharmacokinetics of Glycyrrhizin in Rats with D-Galactosamine-Induced Hepatic Disease
- Disposition of Intravenously Administered Adenosine 5'-Phosphosulfate (APS) in Rats
- STUDIES ON DRUG ABSORPTION FROM ORAL CAVITY. II. INFLUENCE OF THE UNSTIRRED WATER LAYER ON ABSORPTION FROM HAMSTER CHEEK POUCH IN VITRO AND IN VIVO
- Oral Administration of Insulin as Poly(Vinyl Alcohol)-Gel Spheres in Diabetic Rats
- Pharmacokinetics of Acetaminophen Sulfate after Oral Administration in Rats : Analysis of Plasma Profiles Exhibiting a Non-linear Second Peak
- REGIONAL DIFFERENCES IN ORAL-MUCOSAL DRUG ABSORPTION
- Further Investigations of Enhancing Effect of Medium-Chain Triglycerides on d-α-Tocopherol Acetate Absorption from Lecithin-Dispersed Preparations in Rat Small Intestine
- Enhancing Effect of Medium-Chain Triglycerides on Intestinal Absorption of d-α-Tocopherol Acetate from Lecithin-Dispersed Preparations in the Rat
- Pharmacokinetics of Cefpiramide in Rats with Obstructive Jaundice
- DRUG ABSORPTION IN DISEASE STATE : INTESTINAL ABSORPTION OF DRUGS IN RENAL FAILURE RATS
- DIFFERENCES IN EFFECTS ON DRUG ABSORPTION BETWEEN DIHYDROXY AND TRIHYDROXY BILE SALTS
- STUDIES ON DRUG ABSORPTION FROM ORAL CAVITY : PHYSICOCHEMICAL FACTORS AFFECTING ABSORPTION FROM HAMSTER CHEEK POUCH
- ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY WATER-IN-OIL EMULSION
- DEVELOPMENT OF BIFUNCTIONAL DELIVERY SYSTEM FOR SELECTIVE TRANSFER OF DRUG INTO LYMPHATICS VIA ENTERAL ROUTE AND TRANSFER MECHANISM
- ABSORPTION OF 5-FLUOROURACIL FROM VARIOUS REGIONS OF GASTROINTESTINAL TRACT IN RAT. EFFECT OF MIXED MICELLES
- ENHANCED INTESTINAL PERMEABILITY TO MACROMOLECULES. I. EFFECT OF MONOOLEIN-BILE SALTS MIXED MICELLES ON THE SMALL INTESTINAL ABSORPTION OF HEPARIN
- Gastrointestinal Transit and Drug Absorption
- GASTROINTESTINAL TRANSIT AND DRUG ABSORPTION
- Effect of Experimental Acute Renal and Hepatic Failure on Absorption of Tacrolimus in Rat Small Intestine