STUDIES ON DRUG ABSORPTION FROM ORAL CAVITY. II. INFLUENCE OF THE UNSTIRRED WATER LAYER ON ABSORPTION FROM HAMSTER CHEEK POUCH IN VITRO AND IN VIVO
スポンサーリンク
概要
- 論文の詳細を見る
The influence of the unstirred water layer (UWL) adjacent to the membrane surface of the hamster cheek pouch on absorption was studied in vitro and in vivo. The tissue uptake rate of ^<14>C-laurylalcohol was determined in vitro and the value of the effective resistance of UWL (R_w) was calculated. R_w values were reduced by increasing the stirring rate of the mucosal solution. In vitro permeation of ^<14>C-benzoic acid into the serosal compartment was also increased in the well-stirred condition. Thus, the existence of UWL as an effective diffusion barrier for drug absorption from the hamster cheek pouch was suggested. To clarify the influence of the existence of UWL on the absorption in vivo, the apparatus for luminal stirring was newly devised. When the luminal solution was well-stirred, the absorption of benzoic acid in the lower pH region significantly increased, resulting in the disappearance of the shift of pH-absorption curve for benzoic acid. Furthermore, the luminal stirring increased the absorption rate constant for salicylic acid. From these experimental results, it is suggested that UWL plays a part of barriers against drug permeation in the hamster cheek pouch.
- 公益社団法人日本薬学会の論文
著者
-
NAKAYAMA Taiji
Faculty of Pharmaceutical Sciences, Okayama University
-
KUROSAKI Yuhji
Faculty of Pharmaceutical Sciences, Okayama University
-
Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Okayama University
-
Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
-
Hamada Chieko
Faculty Of Pharmaceutical Sciences Okayama University
-
Kurosaki Yuji
Faculty Of Pharmaceutical Sciences Okayama University
-
Kurosaki Yuji
Faculty Of Pharmaceutical Sciences Kyoto University
-
Nakayama T
Faculty Of Pharmaceutical Sciences Okayama University
-
Nakayama Taiji
Faculty Of Pharmaceutical Sciences Okayama University
-
Kimura T
Faculty Of Pharmaceutical Sciences Okayama University
-
HISAICHI SHINICHI
Faculty of Pharmaceutical Sciences, Okayama University
-
Hisaichi Shinichi
Faculty Of Pharmaceutical Sciences Okayama University
-
Kimura Toshikiro
Div. Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
関連論文
- EFFECT OF SURFACTANTS ON THE ABSORPTION OF p-AMINOBENZOIC ACID FROM THE RAT INTESTINE
- COMPARATIVE STUDIES ON THE ABSORPTION MECHANISM OF p-AMINOBENZOIC ACID AND p-ACETAMIDOBENZOIC ACID FROM THE RAT INTESTINE
- ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT SMALL INTESTINE IN SITU
- ABSORPTION AND METABOLISM OF p-AMINOBENZOIC ACID BY RAT INTESTINE IN VITRO
- Factors Determining Drug Residence in Skin during Transdermal Absorption : Studies on β-Blocking Agents
- Study on Glutathionesulfonic Acid Sodium Salt as Biodistribution Promoter for Thiopental Sodium
- Application of 4-Hydroxyantipyrine and Acetaminophen O-Sulfate as Biodistribution Promoter
- Effects of 4-Hydroxyantipyrine and Its 4-O-Sulfate on Antipyrine as Biodistribution Promoter
- Study on Glutathionesulphonic Acid as Biodistribution Promoter : Concomitant Use Effect on Verapamil Hydrochloride and Tegafur
- ELECTROPHYSIOLOGICAL INVERSTIGATIONS ON THE DRUG PERMEATION ACROSS STRATUM CORNEUM (I)
- Effects of Sodium or Glucose Exclusion from the Incubation Medium on Drug Transfer across Rat Jejunal Membrane in Vitro : An Electrophysiological Study(Pharmaceutical)
- EFFECTS OF ABSORPTION PROMOTERS ON THE SELECTIVE PERMEABILITY OF RAT INTESTINAL MEMBRANE TO IONS : ANALYSIS OF PERMEABILITY ENHANCING MECHANISMS BY USING DIFFUSION POTENTIALS
- INVESTIGATIONS OF INFLUX AND ACCUMULATION PROCESSES OF β-LACTAM ANTIBIOTICS AND THEIR ROLE IN THE TRANSMURAL TRANSFER ACROSS RAT JEJUNUM
- FURTHER INVESTIGATIONS ON THE TRANSPORT MECHANISM OF CEPHALEXIN AND AMPICILLIN ACROSS RAT JEJUNUM
- ELECTROPHYSIOLOGICAL APPROACH TO THE ACTION OF TAURINE ON RAT GASTRIC MUCOSA
- EFFECT OF SYNTHETIC SURFACTANTS ON DRUG ABSORPTION IN THE PRESENCE OF A PHYSIOLOGIC SURFACTANT, SODIUM TAUROCHOLATE, IN RATS
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS. II
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : THE MECHANISM OF THE DECREASED ABSORPTION OF SALICYLIC ACID DURING SYSTEMIC ANAPHYLAXIS.I
- AN ASSESSMENT OF GASTRIC ULCERS IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN RATS
- DRUG ABSORPTION FROM THE GASTROINTESTINAL TRACT AND IMMUNITY : EFFECT OF ANAPHYLAXIS ON THE ABSORPTION OF SALICYLIC ACID FROM THE RAT SMALL INTESTINE
- EFFECT OF TAURINE ON THE GASTRIC ABSORPTION OF DRUGS : COMPARATIVE STUDIES WITH SODIUM LAURYL SULFATE
- EFFECT OF TAURINE ON THE GASTROINTESTINAL ABSORPTION OF DRUGS-IONIC REQUIREMENT FOR THE ACTION
- SODIUM ION-DEPENDENCY OF TAURINE-INDUCED ENHANCEMENT OF DRUG ABSORPTION FROM RAT STOMACH IN SITU
- MECHANISM OF THE ABSORPTION OF WATER-SOLUBLE DRUGS FROM THE GASTROINTESTINAL TRACT : ABSORPTION OF β-LACTAM ANTIBIOTICS FROM RAT SMALL INTESTINE
- CARRIER-MEDIATED TRANSPORT SYSTEMS FOR AMINOPENICIL-LINS IN RAT SMALL INTESTINE
- PREPARATION AND BIOPHARMACEUTICAL EVALUATION OF MICROCAPSULES : AMOXICILLIN AND PIRETANIDE
- CHARACTERIZATION OF AMINOCEPHALOSPORIN TRANSPORT ACROSS RAT SMALL INTESTINE
- EFFECT OF TAURINE ON DRUG ABSORPTION FROM THE RAT GASTROINTESTINAL TRACT
- Application of Propranolol to the Keratinized Oral Mucosa : Avoidance of First-Pass Elimination and the Use of 1-Dodecylazacycloheptan-2-one (Azone) as an Absorption Enhancer of Bioadhesive Film-Dosage Form
- ANTITUMOR ACTIVITY OF LIPOPHILIC PRODRUGS OF MITOMYCIN C ENTRAPPED IN LIPOSOME OR O/W EMULSION
- DEVELOPMENT OF LIPOPHILIC MITOMYCIN C PRODRUGS AND THEIR APPLICATION TO LIPID DISPERSION SYSTEMS
- EXPERIMENTAL ANALYSIS OF ANOMALOUS DISPOSITIONS IN DISEASE STATES : DRUG PHARMACOKINETICS IN RATS WITH HEPATIC DISEASES
- Pharmacokinetics of Cefpiramide in Rats Acutely Intoxicated with Carbon Tetrachloride
- FURTHER INVESTIGATIONS ON THE BINDING OF LOOP DIURETICS TO SERUM PROTEINS FROM PATIENTS WITH LIVER DISEASE
- Biopharmaceutical Studies on Drug/Conjugated-Metabolite Interactions. III. Effect of Acetaminophen Sulfate and Its Positional Isomers on the Pharmacokinetics of Acetaminophen in Rats
- Pharmacokinetics of Glycyrrhizin in Rats with D-Galactosamine-Induced Hepatic Disease
- Disposition of Intravenously Administered Adenosine 5'-Phosphosulfate (APS) in Rats
- STUDIES ON DRUG ABSORPTION FROM ORAL CAVITY. II. INFLUENCE OF THE UNSTIRRED WATER LAYER ON ABSORPTION FROM HAMSTER CHEEK POUCH IN VITRO AND IN VIVO
- DESIGN AND SYNTHESIS OF COLON-SPECIFIC PRO-ANTEDRUGS, 20-GLUCOPYRANOSYLOXY METHYLPREDNISOLONATES, FOR ORAL TREATMENT OF ULCERATIVE COLITIS AND THEIR METABOLISM
- Oral Administration of Insulin as Poly(Vinyl Alcohol)-Gel Spheres in Diabetic Rats
- Pharmacokinetics of Acetaminophen Sulfate after Oral Administration in Rats : Analysis of Plasma Profiles Exhibiting a Non-linear Second Peak
- REGIONAL DIFFERENCES IN ORAL-MUCOSAL DRUG ABSORPTION
- Further Investigations of Enhancing Effect of Medium-Chain Triglycerides on d-α-Tocopherol Acetate Absorption from Lecithin-Dispersed Preparations in Rat Small Intestine
- Enhancing Effect of Medium-Chain Triglycerides on Intestinal Absorption of d-α-Tocopherol Acetate from Lecithin-Dispersed Preparations in the Rat
- Pharmacokinetics of Cefpiramide in Rats with Obstructive Jaundice
- DRUG ABSORPTION IN DISEASE STATE : INTESTINAL ABSORPTION OF DRUGS IN RENAL FAILURE RATS
- DIFFERENCES IN EFFECTS ON DRUG ABSORPTION BETWEEN DIHYDROXY AND TRIHYDROXY BILE SALTS
- STUDIES ON DRUG ABSORPTION FROM ORAL CAVITY : PHYSICOCHEMICAL FACTORS AFFECTING ABSORPTION FROM HAMSTER CHEEK POUCH
- Gastrointestinal Transit and Drug Absorption
- GASTROINTESTINAL TRANSIT AND DRUG ABSORPTION