Enhancing Effect of Medium-Chain Triglycerides on Intestinal Absorption of d-α-Tocopherol Acetate from Lecithin-Dispersed Preparations in the Rat
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概要
- 論文の詳細を見る
The effect of formulations of lecithin-dispersed preparation on the absorption of d-α-tocopherol acetate (VEA) from the small intestine was investigated in rats. When lecithin-dispersed preparations containing VEA or polysorbate 80 (PS-80)-solubilized solution of VEA were intraduodenally administered, VEA was hydrolyzed to d-α-tocopherol (VE) and was not detected in the plasma nor in the thoracic lymph. The maximum plasma concentration (C_<max>) of VE after the intraduodenal administration of a preparation consisting of VEA, soybean phosphatidylcholine (PC) and medium-chain triglycerides (MCTG) (VEA/PC/MCTG, 5/16/1 by weight) was highest among the VEA preparations, and PS-80-solubilized solution gave the lowest C_<max>. AUC of VE up to 24 h was also increased by the addition of MCTG to VEA/PC preparation. In the thoracic duct-fistula rat, the transport of VE into the thoracic lymph was increased by the administration of the VEA/PC/MCTG preparation significantly more than the VEA/PC preparation ; the cumulative amounts of VE recovered in the thoracic lymph up to 24 h were 23.2±0.5% and 10.9±1.5% of dose, respectively. The plasma concentration of VE was not increased in the thoracic duct-fistula rat even after the intraduodenal administration of VEA preparations, suggesting that VE is not transported directly to the systemic circulation, but by way of the lymphatic route. The lymphatic transport of VE following the intraduodenal administration of VEA/PC/MCTG preparation was markedly diminished by the simultaneous administration of Pluronic L-81 emulsion, an inhibitor of chylomicron formation. It is suggested that the chylomicron is essential to the lymphatic transport of VE from VEA preparations.
- 公益社団法人日本薬学会の論文
著者
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NAKAYAMA Taiji
Faculty of Pharmaceutical Sciences, Okayama University
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KUROSAKI Yuhji
Faculty of Pharmaceutical Sciences, Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Faculty Of Pharmaceutical Sciences Kyoto University
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Kurosaki Yuji
Faculty Of Pharmaceutical Sciences Okayama University
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Kurosaki Yuji
Faculty Of Pharmaceutical Sciences Kyoto University
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Nakayama T
Faculty Of Pharmaceutical Sciences Okayama University
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Nakayama Taiji
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura T
Faculty Of Pharmaceutical Sciences Okayama University
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FUKUI Eiji
Faculty of Pharmaceutical Sciences, Okayama University
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KUROHARA Harumi
Faculty of Pharmaceutical Sciences, Okayama University
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KAGEYU Akira
Faculty of Pharmaceutical Sciences, Okayama University
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Fukui Eiji
Faculty Of Pharmaceutical Sciences Okayama University
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Kobayashi Akira
Faculty Of Pharmaceutical Sciences Okayama University
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Kurohara Harumi
Faculty Of Pharmaceutical Sciences Okayama University
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Kimura Toshikiro
Div. Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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