Study on Glutathionesulfonic Acid Sodium Salt as Biodistribution Promoter for Thiopental Sodium

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概要

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• The effects of glutathione (GSH) and glutathionesulfonic acid sodium salt[N-(N-γ-L-glutamyl-L-β-sul-foalanyl)glycine sodium salt, GSO_3Na], which is a minor metabolite of GSH, on the pharmacokinetics of thiopental sodium were investigated in rats. The concomitant use of GSO_3Na with thiopental sodium significantly increased the tissue-to-plasma concentration ratio (K_p) of thiopental sodium 60 min after its administration in the heart, lung, brain, liver, kidney, and spleen, while GSH did not affect them. On the other hand, the value of thiopental sodium 5 mm after its administration with concomitant GSO_3Na decreased significantly only in the spleen. Neither GSO_3Na nor GSH changes the pharmacokinetic parameters of thiopental sodium. Significant change of the binding ratio of thiopental sodium to bovine serum albumin (BSA) was not observed by the addition of less than 5-fold GSO_3Na. About 50% of thiopental sodium was bound to the brain, lung or liver, however,no significant change of this binding ratio was observed by the concomitant use of GSO_3Na. The partition coefficient of thiopental sodium apparently increased by the concomitant use of GSO_3Na but not by GSH. This phenomenon seemed to be concerned with a mechanism to increase the values of thiopental sodium in the tissues. The increment in the drug distribution to tissues with concomitant GSO_3Na observed in this study is useful information for the application of drug combinations as a biodistribution promoter.

• 公益社団法人日本薬学会の論文
• 2002-06-01

著者

• Sasaki K

  Faculty Of Pharmaceutical Sciences Okayama University

• SASAKI Kenji

  Faculty of Pharmaceutical Sciences, Okayama University

• Sasaki K

  Tohoku Pharmaceutical Univ. Sendai Jpn

• OHKAWA Yuhsuke

  Faculty of Pharmaceutical Sciences, Okayama University

• FUJIMOTO Tomonori

  Faculty of Pharmaceutical Sciences, Okayama University

• HIGASHIYAMA Kyohko

  Faculty of Pharmaceutical Sciences, Okayama University

• MAEDA Hiroshi

  Faculty of Pharmaceutical Sciences, Okayama University

• ASOH Tomoyuki

  Faculty of Pharmaceutical Sciences, Okayama University

• KURUMI Masateru

  Faculty of Pharmaceutical Sciences, Okayama University

• NAKAYAMA Taiji

  Faculty of Pharmaceutical Sciences, Okayama University

• Asoh Tomoyuki

  Faculty Of Pharmaceutical Sciences Okayama University

• Ohkawa Yuhsuke

  Faculty Of Pharmaceutical Sciences Okayama University

• Nakayama T

  Faculty Of Pharmaceutical Sciences Okayama University

• Nakayama Taiji

  Faculty Of Pharmaceutical Sciences Okayama University

• Kurumi M

  Faculty Of Pharmaceutical Sciences Okayama University

• Higashiyama Kimio

  Institute Of Medicinal Chemistry Hoshi University

• Fujimoto Tomonori

  Faculty Of Pharmaceutical Sciences Okayama University

• Sasaki Kenji

  Faculty Of Engineering University Of Yamanashi

• Maeda Hiroshi

  Faculty Of Pharmaceutical Sciences Okayama University:kumamoto University Medical School

• Maeda Hiroshi

  Faculty Of Engineering Kyushu Institute Of Technology

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