Polycyclic N-Heterocyclic Compounds. Part 60: Reactions of 3-(2-Cyanophenyl)quinazolin-4(3H)-ones with Primary Amines

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概要

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• The reaction of 3-(2-cyanophenyl)quinazolin-4(3H)-one with various primary alkylamines gave 3-alkylquinazolin-4(3H)-ones via an addition of the nucleophile, ring opening, and ring closure (ANRORC) mechanism. This type of reaction required hydroxy group functionality in either the solvent or reagent. When hydroxylamine was used as nitrogen nucleophile, the intermediate of this reaction was isolated and found to be an amide oxime. When ethylenediamine was used as the nucleophile, the amidine moiety of the intermediate decomposed to give a benzanilide.

• 公益社団法人　日本薬学会の論文

著者

• KASHINO Setsuo

  Department of Chemistry, Faculty of Science, Okayama University

• SASAKI Kenji

  Faculty of Pharmaceutical Sciences, Okayama University

• HIROTA Takashi

  Faculty of Pharmaceutical Sciences, Okayama University

• Hirota Takashi

  Faculty Of Pharmaceutical Sciences Okayama University:faculty Of Pharmaceutical Sciences Kumamoto Un

• Kashino Setsuo

  Department Of Chemistry Faculty Of Science Okayama University

• Okuda Kensuke

  Gifu Pharmaceutical University

• Tagata Tsuyoshi

  Faculty of Pharmaceutical Sciences, Okayama University

• Sasaki Kenji

  Faculty Of Engineering University Of Yamanashi

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