Polycyclic N-Heterocyclic Compounds. Part 62: Reaction of N-(Quinazolin-4-yl)amidine Derivatives with Hydroxylamine Hydrochloride and Anti-platelet Aggregation Activity of the Products
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概要
- 論文の詳細を見る
The reactions of N-(5,6,7,8-tetrahydroquinazolin-4-yl)amidines and their amide oximes with hydroxylamine hydrochloride gave abnormal cyclization products via a ring cleavage of pyrimidine component accompanied with a ring closure of 1,2,4-oxadiazole to give N-[2-([1,2,4]oxadiazol-5-yl)cyclohexen-1-yl]formamide oximes. Similarly, N-(quinazolin-4-yl)amidines reacted with hydroxylamine hydrochloride gave the same results. The evaluation of inhibitory activities against platelet aggregation in vitro is also described to show one derivative has potent activity.
- 公益社団法人 日本薬学会の論文
著者
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SASAKI Kenji
Faculty of Pharmaceutical Sciences, Okayama University
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HIROTA Takashi
Faculty of Pharmaceutical Sciences, Okayama University
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Hirota Takashi
Faculty Of Pharmaceutical Sciences Okayama University:faculty Of Pharmaceutical Sciences Kumamoto Un
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Okuda Kensuke
Gifu Pharmaceutical University
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Zhang Ying-Xue
Faculty of Pharmaceutical Sciences, Okayama University
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Ohtomo Hiromi
Faculty of Pharmaceutical Sciences, Okayama University
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Sasaki Kenji
Faculty Of Engineering University Of Yamanashi
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