Diastereoselective Addition of Grignard Reagents to Chiral 1,3-Oxazolidines Having a N-Diphenylmethyl Substituent
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概要
- 論文の詳細を見る
Chiral 1,3-oxazolidines having a diphenylmethyl group at the 3-position of the oxazolidine ring as a bulky substituent were synthesized. The reaction of Grignard reagents with the chiral 1,3-oxazolidines afforded the corresponding amines with very high diastereoselectivity. Furthermore, the method for the synthesis of optically active amines was applied to the asymmetric synthesis of (-)-dihydropinidine, a piperidine alkaloid.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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Higashiyama Kimio
Institute Of Medicinal Chemistry Hoshi University
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Yamauchi Takayasu
Institute Of Medicinal Chemistry Hoshi University
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TAKAHASHI HIROSHI
Institute of Industrial Science, The University of Tokyo
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Takahashi Hiroshi
Institute Of Industrial Science The University Of Tokyo
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Takahashi Hiroshi
Institute Of Medicinal Chemistry Hoshi University
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- Diastereoselective Addition of Grignard Reagents to Chiral 1,3-Oxazolidines Having a N-Diphenylmethyl Substituent
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