The Hypoglycemic Effect of (7R^*, 9aS^*)-7-Phenyl-octahydroquinolizin-2-one in Mice
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概要
- 論文の詳細を見る
(-)-Multiflorine (1), which was isolated from leguminous plants, produced a hypoglycemic effect when administered to mice with streptozotocin-induced diabetes. (-)-Multiflorine has an enaminone type conjugation on the A-ring, which is unusual in lupine alkaloids. Proceeding on the assumption that the A-B ring is responsible for the activity, several compounds bearing quinolizidin-2-one were synthesized and their hypoglycemic effects were examined. The hypoglycemic effect of (7R^*, 9aS^*)-7-phenyl-octahydroquinolizin-2-one was approximately 4 times stronger than that of (-)-multiflorine measured by oral glucose tolerance test in normal mice. This result indicates that compounds possessing the quinolizidin-2-one ring system as the basic structure may be possible lead compounds for a new type of diabetes drug.
- 公益社団法人日本薬学会の論文
- 2000-09-01
著者
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Ohmiya Shigeru
中華人民共和国
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Ohmiya S
Hoshi Univ. Tokyo Jpn
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Kobayashi J
Optoelectronics Joint Research Laboratory:(present Address) Material & Electronic Devices Labora
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Kubo H
New Product Research Laboratories Ii Daiichi Pharmaceutical Company Ltd.
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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KUBO Hajime
Faculty of Medicinal Chemistry; Hoshi University
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KUBO Hajime
Institute of Medicinal Chemistry, Hoshi University
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HIGASHIYAMA Kimio
Institute of Medicinal Chemistry, Hoshi University
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OHMIYA Shigeru
Institute of Medicinal Chemistry, Hoshi University
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Fujii Yuji
Central Research Laboratories Tsumura Inc.
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Kamei J
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
国立精神･神経センター精神保健研究所 老人精神保健部
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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KOBAYASHI Junji
Institute of Medicinal Chemistry, Hoshi University
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Kobayashi J
Institute Of Medicinal Chemistry Hoshi University
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Higashiyama Kimio
Institute Of Medicinal Chemistry Hoshi University
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Higashiyama K
Faculty Of Pharmaceutical Sciences Okayama University
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