Effects of Methylphenidate on the Hyperemotional Behavior in Olfactory Bulbectomized Mice by Using the Hole-Board Test
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概要
- 論文の詳細を見る
The most consistent behavioral changes caused by olfactory bulbectomy are hyperemotional responses such as hyperactivity in a novel environment. However, the changes in the emotional behavior of mice after undergoing olfactory bulbectomy have not yet been described in detail. The effects of methylphenidate on the hyperemotional behavior of olfactory bulbectomized (OBX) mice were examined by using the hole-board test. Mice (4-week-old) were subjected to olfactory bulbectomy, and the behavioral test was performed 2 weeks after surgery. OBX mice showed a significant increase in the number of head-dips as compared to the sham-operated mice. This increase was significantly decreased after treatment with methylphenidate (10 μg/kg, s.c.). The norepinephrine (NE) turnover ratio in the frontal cortex in OBX mice was significantly less than that in the sham-operated mice. However, the decreased NE ratio in OBX mice normalized after treatment with methylphenidate. Our results suggest that the increased head-dipping behavior in OBX mice might reflect an impulsive-like behavior. In addition, we proposed that the improvement in the noradrenergic abnormalities in the frontal cortex due to methylphenidate treatment may play a key role in the improvement of impulsive-like behaviors observed in OBX mice.
- 社団法人 日本薬理学会の論文
- 2007-02-20
著者
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SAITOH Akiyoshi
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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Yamada Mitsuhiko
Department of Molecular Pharmacology, Shinshu University School of Medicine
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Saitoh Akiyoshi
Department Of Pathophysiology & Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hosh
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HIROSE Noritaka
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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OKA Takuma
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi
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MIYATA Shigeo
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi
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Hirose Noritaka
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Oka Takuma
Department Of Pathophysiology & Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hosh
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Yamada Mitsuhiko
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Kamei J
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
国立精神･神経センター精神保健研究所 老人精神保健部
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Miyata Shigeo
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Yamada Mitsuhiko
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Saitoh A
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Saitoh Akiyoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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Hirose Noritaka
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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SAITOH Akiyoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry
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