Effects of Serotonergic Anxiolytics on the Freezing Behavior in the Elevated Open-Platform Test in Mice
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概要
- 論文の詳細を見る
Freezing behavior is thought to be a sign of fear in animals. We examined whether the freezing behavior during the elevated open-platform stress, which is a psychological stressor without painful stimulus, is modulated by serotonergic neurotransmission and would be a useful marker for screening anxiolytic and/or antidepressant. Male ICR mice (6 – 8-week-old) were individually placed on an elevated open-platform and the duration of freezing behavior of mouse was measured for 10 min. Fluoxetine and citalopram, selective serotonin (5-HT) reuptake inhibitors, markedly decreased the duration of freezing. Fenfluramine, a 5-HT releaser, and 8-OH-DPAT, a potent 5-HT1A-receptor agonist, also significantly decreased the duration of freezing. In contrast, the 5-HT-synthesis inhibitor p-chlorophenylalanine significantly increased the duration of freezing. Diazepam, a benzodiazepine anxiolytic, had no effect on the duration of freezing at doses having no effect on locomotor activity. Imipramine and clomipramine, tricyclic antidepressants, also did not affect the duration of freezing. Reboxetine, a selective noradrenaline reuptake inhibitor, significantly increased the duration of freezing. These results indicate that the activation of serotonergic neurotransmission attenuates the fear-related behavior in the elevated open-platform test, while the activation of noradrenergic neurotransmission increases the fear-related behavior. In addition, this test is convenient for assaying anxiolytic drugs that affect serotonergic neurotransmission.
- 社団法人 日本薬理学会の論文
- 2007-11-20
著者
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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MIYATA Shigeo
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi
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HIRANO Shoko
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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Hirano Shoko
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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YAMADA Naoko
Department of Pathology, Institute for Advanced Medical Sciences, Hyogo College of Medicine
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Yamada Naoko
Department Of Pathology Institute For Advanced Medical Sciences Hyogo College Of Medicine
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Ohsawa Masahiro
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Ohsawa Masahiro
Department Of Endodontics And Operative Dentistry Nagasaki University School Of Dentistry
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Hata Yoko
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Kamei J
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
国立精神･神経センター精神保健研究所 老人精神保健部
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Miyata Shigeo
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Ohsawa M
Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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SHIMOI Toshiko
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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YOSHIKAWA Naoki
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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Shimoi Toshiko
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Yoshikawa Naoki
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Yamada Naoko
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Yamada Naoko
Department Of Pathology Hyogo College Of Medicine
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