Potentiation of the Antidepressant-Like Effect of Fluoxetine by Aripiprazole in the Mouse Tail Suspension Test
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概要
- 論文の詳細を見る
We examined the effect of the novel atypical antipsychotic drug aripiprazole alone or in combination with the selective serotonin reuptake inhibitor fluoxetine in the mouse tail suspension test. We also investigated the effect of aripiprazole on glucose metabolism. Combined treatment with aripiprazole and a sub-effective dose of fluoxetine significantly decreased the duration of immobility in the tail suspension test. Aripiprazole by itself did not affect the duration of immobility. While olanzapine significantly increased blood glucose level in the glucose tolerance test, aripiprazole did not affect glucose metabolism. We suggest that aripiprazole augments the antidepressant-like effect of fluoxetine without affecting glucose metabolism.
- 社団法人 日本薬理学会の論文
- 2008-11-20
著者
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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MIYATA Shigeo
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi
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Ohsawa Masahiro
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Ohsawa Masahiro
Department Of Endodontics And Operative Dentistry Nagasaki University School Of Dentistry
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Kamei J
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
国立精神･神経センター精神保健研究所 老人精神保健部
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Miyata Shigeo
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Ohsawa M
Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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SUNOHARA Takayuki
Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hosh
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KAMEI Atsuko
Mine Pharmacy
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SHIMADA Masahiko
Division of Applied of Pharmaceutical Education and Research, School of Pharmacy and Pharmaceutical
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Sunohara Takayuki
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Shimada Masahiko
Division Of Applied Of Pharmaceutical Education And Research School Of Pharmacy And Pharmaceutical S
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