Effects of Morphine on Responses of Nociceptive Ventrobasal Thalamic Neurons in Diabetic Rats.
スポンサーリンク
概要
- 論文の詳細を見る
The influence of diabetes on the effects of morphine on the responses of ventrobasal (VB) thalamic neurons to mechanical noxious stimuli were studied in chloral hydrate-anesthetized rats. Animals were rendered diabetic by an injection of streptozotocin (60 mg/kg, i.v.). Morphine (0.3 mg/kg), administered i.v., produced a reduction in the responsiveness of VB thalamic neurons to noxious stimulation in control rats. This effect was reversed by naloxone. In contrast, the inhibitory effects of morphine on the nociceptive responses of VB thalamic neurons were significantly attenuated in diabetic rats, as compared with the controls. However, there were no significant differences in inhibitory potency between diabetic and control rats when morphine (30 nM) was administered intrathecally. It seems likely that these changes in the sensitivity of VB thalamic neurons to morphine are, to some extent, the source of the reduction in the analgesic efficacy of morphine in diabetic rats.
- 公益社団法人 日本薬理学会の論文
著者
-
Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
-
Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Aoki Taro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
-
Hitosugi Hideki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
-
Iwamoto Yuriko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University
関連論文
- Effects of Chronic Administration of Zonisamide, an Antiepileptic Drug, on Bone Mineral Density and Their Prevention With Alfacalcidol in Growing Rats
- ATTENUATION OF THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS BY CHRONIC ORAL ADMINISTRATION OF EICOSAPENTAENOIC ACID
- Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants
- Effects of Methylphenidate on the Hyperemotional Behavior in Olfactory Bulbectomized Mice by Using the Hole-Board Test
- Changes in Emotional Behavior of Mice in the Hole-Board Test After Olfactory Bulbectomy
- Effects of First- and Second-Generation Histamine-H_1-Receptor Antagonists on the Pentobarbital-Induced Loss of the Righting Reflex in Streptozotocin-Induced Diabetic Mice
- Antinociceptive Mechanism of Gosha-jinki-gan in StreptozotocinInduced Diabetic Animals: Role of Nitric Oxide in the Periphery
- Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice
- Effect of Gosha-jinki-gan, a Kampo Medicine, on Enhanced Platelet Aggregation in Streptozotocin-Induced Diabetic Rats
- Elucidation With the Protease α-Chymotrypsin of the Inhibitory Modulating Action of Endogenous Neuropeptide Y Over Sympathetic Neurotransmission in Rat Vas Deferens
- Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents
- TRK-820, a Selective к-Opioid Agonist, Produces Potent Antinociception in Cynomolgus Monkeys
- INHIBITORY EFFECTS OF HISTAMINE ON CONTRACTION INDUCED BY TRANSMURAL STIMULATION IN RAT VAS DEFERENS
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. I. : Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.
- Involvement of α_2-Adrenergic Receptors in the Vagal Reflex-Induced Tracheal Constriction
- INHIBITION OF THE VAGAL REFLEX-INDUCED TRACHEAL CONSTRICTION BY PSYCHOTROPIC DRUGS
- Mechanisms of Increased Responses of the Aorta to α-Adrenoceptor Agonists in Streptozotocin-Induced Diabetic Rats
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. III. ACTIONS ON CARDIOVASCULAR SYSTEM AND ACUTE TOXICITY
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. II. AGONISTIC AND ANTAGONISTIC ACTIONS ON α-ADRENOCEPTORS IN VARIOUS SMOOTH MUSCLE PREPARATIONS
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. I. A COMPARISON OF THE EFFECT ON PRE- AND POSTSYNAPTIC α-ADRENOCEPTORS IN THE RAT VAS DEFERENS
- Further Studies Concerning Possible Transmitters from NANC Nerves in the Circular Muscle of the Rat Stomach Fundus
- PLATELET ACTIVATING FACTOR : LACK OF DIRECT CARDIAC ACTION AND POSSIBLE TRANSMITTER RELEASE FROM CARDIAC SYMPATHETIC NERVE ENDINGS AT HIGH CONCENTRATIONS. ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES WITH GUINEA PIG VENTRICULAR MYOCARDIUM
- Effects of Calmodulin Antagonist (W-7) on Phorbol Ester (PMA)-induced Contractile Response in Isolated Rat Aorta
- Effect of phorbol 12, 13-dibutyrate on smooth muscle tone in rat stomach fundus
- Diabetes-related changes in contractile responses of stomach fundus to endothelin-1 in streptozotocin-induced diabetic rats
- Pitavastatin Inhibits Vascular Smooth Muscle Cell Proliferation by Inactivating Extracellular Signal-Regulated Kinases 1/2
- POTENTIATION BY BOVINE SERUM ALBUMIN (BSA) OF ENDOTHELIUM-DEPENDENT VASODILATOR RESPONSE TO ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE (AGEPC)
- Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1
- Differences in cell kinetic changes among renal cancer cell lines treated with interferon-α
- The effect of papaverine on morphologic differentiation,proliferation and invasive potential of human prostatic cancer LNCaP cells
- Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine-and (+)-Allomatrine-Induced Antinociceptive Effects(Medicinal Chemistry)
- Modification of the Effects of Benzodiazepines on the Exploratory Behaviors of Mice on a Hole-Board by Diabetes
- Hypoglycemic Effects of Multiflorine Derivatives in Normal Mice(Medicinal Chemistry)
- The Hypoglycemic Effect of (7R^*, 9aS^*)-7-Phenyl-octahydroquinolizin-2-one in Mice
- RENAL MICROSOMAL N-NITROSODIMETHYLAMINE DEMETHYLASE DETERMINED BY A SENSITIVE RADIOMETRIC METHOD
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. II. : Hepatotoxicity by the simultaneous administration of several drugs and nitrite.
- P-532 Structure-Antitussive Activity Relationships of Naltrindole Derivatives : Discovery of Novel and Potent Antitussive Agents
- Effects of Serotonergic Anxiolytics on the Freezing Behavior in the Elevated Open-Platform Test in Mice
- EFFECTS OF HYPOXIA AND REOXYGENATION ON TISSUE ATP LEVEL AND ELECTRICAL AND MECHANICAL FUNCTION OF ISOLATED GUINEA PIG VENTRICULAR MUSCLES.
- EFFECTS OF HYPOXIA AND METABOLIC INHIBITORS ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF ISOLATED GUINEA PIG PAPILLARY MUSCLES
- ELECTROPHYSIOLOGICAL EFFECTS OF A NEW ANTIARRHYTHMIC AGENT, LORCAINIDE, ON THE ISOLATED CARDIAC MUSCLE FIBER AS COMPARED WITH DISOPYRAMIDE
- Antinociceptive Effect of Vitamin K_2 (Menatetrenone) in Diabetic Mice
- Effects of L-Tryptophan on the Effects of Antitussives
- Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord
- Potentiation of the Antidepressant-Like Effect of Fluoxetine by Aripiprazole in the Mouse Tail Suspension Test
- Effects of Double-enkephalin (Biphalin), an Enkephalin Analogue, on Respiration and the Cough Reflex in Rats
- Effect of Diabetes on the Morphine-Induced Inhibition of Gastrointestinal Tranist
- Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice
- Effects of T-82, a New Quinoline Derivative, on Cholinesterase Activity and Extracellular Acetylcholine Conventration in Rat Brain
- Effect of Mexiletine on Fenvalerate-Induced Nociceptive Response in Diabetic Mice
- Modification of the Expression of Naloxone-Precipitated Withdrawal Signs in Morphine-Dependent Mice by Diabetes : Possible Involvement of Protein Kinase C
- NEGATIVE CHRONOTROPIC EFFECT OF DIBUTYRYL CYCLIC AMP ON THE CULTURED CHICK EMBRYONIC HEART CELLS AND THE PROLONGATION OF THE ACTION POTENTIAL DURATION
- THE MECHANISM OF AGGRAVATION OF INDOMETHACIN-INDUCED GASTRIC ULCERS BY ADRENALECTOMY IN THE RAT
- Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
- EFFECTS OF SMOOTH MUSCLE STIMULANTS ON I-ISOPRENALINE-β-ADRENOCEPTOR INTERACTION IN TAENIA FROM GUINEA PIG CAECUM
- Inhaled Pinacidil, an ATP-Sensitive K+ Channel Opener, and Moguisteine Have Potent Antitussive Effects in Guinea Pig
- EFFECTS OF VARIOUS DRUGS AND VAGOTOMY ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN THE RAT
- INHIBITORY ALPHA-ADRENERGIC ACTION OF PHENYLEPHRINE IN GUINEA PIG TAENIA CAECUM
- EFFECTS OF COCAINE ON Ca-MOBILITY IN MICROSOMAL FRACTION FROM RAT VAS DEFERENS
- EFFECTS OF ACETYLCHOLINE AND HISTAMINE ON MECHANICAL ACTIVITY OF RABBIT TAENIA COLI, Ca-INCORPORATION AND Ca-RELEASE IN ITS MICROSOMAL FRACTION
- NONSPECIFIC RELAXATION OF INTESTINAL SMOOTH MUSCLE INDUCED BY ANTISPASMODICS AND MOVEMENT OF CALCIUM IONS
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY IN DEPOLARIZED TAENIA CAECUM OF GUINEA PIG
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON TISSUE CONCENTRATIONS OF HIGH ENERGY PHOSPHATES AND MECHANICAL ACTIVITY OF NORMAL POLARIZED AND DEPOLARIZED INTESTINAL SMOOTH MUSCLES FROM GUINEA PIG
- POSSIBLE ROLE OF ENDOTHELIUM IN THE VASODILATOR RESPONSE OF RAT THORACIC AORTA TO PLATELET ACTIVATING FACTOR (PAF)
- STUDIES ON THE HYPOTENSIVE EFFECTS OF PLATELET ACTIVATING FACTOR (PAF, 1-o-ALKYL-2-ACETYL-sn-GLYCERYL-3-PHOSPHORYLCHOLINE) IN RATS, GUINEA PIGS, RABBITS, AND DOGS
- ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES ON THE CARDIAC EFFECTS OF A HISTAMINE H_2 RECEPTOR ANTAGONIST, CIMETIDINE, IN THE ISOLATED GUINEA PIG MYOCARDIUM
- EVIDENCE FOR A DIRECT ACTION OF X-537A ON THE CARDIAC PLASMA MEMBRANE AS AN IONOPHORE
- Preservation of Endothelium-Dependent Vascular Relaxation in Cholesterol-Fed Mice by the Chronic Administration of Prazosin or Pravastatin
- INHIBITION BY PROPRANOLOL OF HIGH POTASSIUM-INDUCED CONTRACTIONS IN THE RAT VAS DEFERENS
- A COMPARATIVE STUDY OF CHANGES IN INNERVATION AND DEVELOPMENT OF SUPERSENSITIVITY IN THE RAT VAS DEFERENS AFTER VARIOUS PROCEDURES
- EFFECTS OF VARIOUS DRUGS AND EXTRINSIC DENERVATION ON THE NON-ADRENERGIC INHIBITORY NEURONS IN THE RAT STOMACH
- Effects of Streptozotocin-Induced Diabetes on Place Conditioning Action of Cocaine in Mice
- RENAL TOXICITY OF ADENOSINE 3', 5'-CYCLIC MONOPHOSHATE IN MICE.
- ACUTE TOXICITY OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE
- CARDIOTONIC EFFECT OF PHTHALAZINOL (EG-626) IN THE ISOLATED GUINEA PIG MYOCARDIUM : MECHANICAL AND ELECTROPHYSIOLOGICAL STUDY
- Nociception and Allodynia/Hyperalgesia Induced by Intrathecal Administration of Fenvalerate
- EFFECTS OF 8-(2-FLUOROETHYL)-3α-HYDROXY-lαH, 5αH-TROPANIUMBROMIDE BENZILATE (Ba598Br) ON ALLERGY AND DRUG-INDUCED ASTHMAS
- ANALYSIS OF EFFERENT DISCHARGES OF THE PHRENIC NERVE DURING THE COUGH REFLEX
- EFFECTS OF 15(S)-15-METHYL-PGE2 METHYL ESTER ON HEALING OF CHRONIC GASTRIC AND DUODENAL ULCERS IN RATS
- DESENSITIZATION OF GUINEA PIG TRACHEAL MUSCLE PREPARATION TO BETA-ADRENERGIC STIMULANTS BY A PRECEDING EXPOSURE TO A HIGH DOSE OF CATECHOLAMINES
- INFLUENCE OF SURGICAL SYMPATHECTOMY ON GASTRIC SECRETION AND ULCERATION IN RATS
- GASTRIC ACID SECRETION IN BEAGLE DOGS USING INTRAMUSCULAR INJECTION OF STIMULANTS
- RHYTHMIC CONTRACTIONS INDUCED BY VAGOTOMY IN THE FUNDUS OF RAT STOMACH
- Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats
- SELECTIVE ABOLITION OF Ca-DEPENDENT RESPONSES OF SMOOTH AND CARDIAC MUSCLES BY FLUNARIZINE
- EFFECTS OF COCAINE AND TETRAETHYLAMMONIUM ON THE SPIKE POTENTIALS AND CONTRACTIONS INDUCED BY TRANSMURAL STIMULATION IN THE RAT VAS DEFERENS
- EFFECTS OF OXIMES, DIACETYLMONOXIME, PYRIDINE-2-ALDOXIME, AND PYRIDINE-2-ALDOXIME METHOCHLORIDE, ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF GUINEA PIG CARDIAC VENTRICULAR MUSCLES
- Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors
- Inhibitory Reflex during Bronchoconstrictions Induced by Histamine and Ascaris Suum Antigen.
- Involvement of central serotonergic mechanisms in the cough reflex.
- Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective .DELTA.-Opioid Agonist, in Behavioral Models in Rodents
- Analysis of the vagal reflex tracheal constriction in the dog.
- Changes in Emotional Behavior of Mice in the Hole-Board Test After Olfactory Bulbectomy
- Antitussive effect of RU-20201 - Central and peripheral actions.
- Effects of methysergide on the cough reflex.
- Effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine.
- Effects of Morphine on Responses of Nociceptive Ventrobasal Thalamic Neurons in Diabetic Rats.
- Blockade of .DELTA.-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice.
- Inhibitory modulation on the reflex tracheal constriction induced by afferent vagal stimulation.
- Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat : Role of Accumbal Non-dopaminergic Receptors