Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors
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概要
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Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson’s disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they interact with dopaminergic function: this is because modifying accumbal dopamine has far-reaching consequences for the treatment of diseases in which accumbal dopamine is involved. This review provides a summary of these interactions, and our current knowledge about them are as follows: A) AMPA receptors are required for dopamine-dependent behavior and <I>vice versa</I>; NMDA receptors modulate the activity at the level of AMPA and/or dopamine D<SUB>1</SUB> receptors. B) GABA<SUB>A</SUB>, but not GABA<SUB>B</SUB>, receptors inhibit dopamine-dependent behavior. C) Nicotinic receptors are required for dopamine-dependent behavior, whereas muscarinic receptors inhibit dopamine-dependent behavior. D) <I>α</I>-Adrenoceptors inhibit dopamine-dependent behavior in contrast to <I>β</I>-adrenoceptors, which potentiate this behavior. E) <I>μ</I>- and <I>δ</I><SUB>2</SUB>-opioid receptors elicit behavior that requires an intact dopaminergic function and <I>δ</I><SUB>2</SUB>-opioid receptors modulate dopamine-dependent behavior. F) Orexin 2 receptors play an important, modifying role in dopamine-dependent behavior. G) Somatostatin receptors potentiate dopamine-dependent behavior. It is suggested that modulation of the above-mentioned non-dopaminergic receptors provide new tools to control physiological functions as well as diseases mediated by accumbal dopamine.
著者
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Koshikawa Noriaki
Department Of Pharmacology Dental Research Center Nihon University School Of Dentistry
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Ikeda Hiroko
Department Of Anatomy And Histology Fukushima Medical University School Of Medicine
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Cools Alexander
Radboud University Medical Centre Nijmegen, Donders Institute for Brain, Cognition and Behavior
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Cools Alexander
Radboud University Medical Centre Nijmegen, Donders Institute for Brain, Cognition and Behavior: Psychoneuropharmacology, The Netherlands
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