5-HT1A and 5-HT1B receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats
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概要
- 論文の詳細を見る
The ability of serotonin 5-HT<Sub>1A</Sub> and 5-HT<Sub>1B</Sub> receptors in the ventrolateral striatum to modulate dopamine receptor-mediated jaw movements was investigated in freely moving rats, using a magnet-sensing system combined with an intracerebral drug microinjection technique. Apomorphine (1 mg/kg i.v.) has been found to elicit repetitive jaw movements. Bilateral injections of the 5-HT<Sub>1A</Sub> receptor agonist 8-OH-DPAT (1 and 4 μg/0.2 μl in each side) into the ventrolateral striatum partially but significantly reduced apomorphine-induced repetitive jaw movements. The 5-HT<Sub>1A</Sub> receptor antagonist WAY-100635 (1 μg), which alone did not affect the effects of apomorphine, antagonized the inhibitory effects of 8-OH-DPAT (4 μg). Bilateral injections of the 5-HT<Sub>1B</Sub> receptor agonist CP93129 (1 and 10 μg) also reduced apomorphine-induced repetitive jaw movements in a dose-dependent manner. However, the 5-HT<Sub>1B</Sub> receptor antagonist GR55562 (1 and 10 μg) did not antagonize the inhibitory effects of CP93129 (10 μg). These results suggest that 5-HT<Sub>1A</Sub>, but not 5-HT<Sub>1B</Sub>, receptors in the ventrolateral striatum play a modulatory role in the production of dopamine receptor-mediated jaw movements. (J. Oral Sci. 50, 387-395, 2008)
- 日本大学歯学部の論文
著者
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Koshikawa Noriaki
Department Of Pharmacology Dental Research Center Nihon University School Of Dentistry
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Fujita Satoshi
Department Of Anesthesiology School Of Medicine Sapporo Medical University
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Suga Kurando
Department Of Orthodontics School Of Dental Medicine Tsurumi University
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Lee Jun
Department of Biology, College of Natural Sciences, Chosun University
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Suga Kurando
Department of Pharmacology, Nihon University School of Dentistry
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Kiguchi Motori
Department of Orthodontics, Nihon University School of Dentistry
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Terakado Masanori
Department of Pharmacology, Nihon University School of Dentistry
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Hatanaka Hiroshige
Department of Pharmacology, Nihon University School of Dentistry
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