Expression profiles of MUC mucin core protein in the intrahepatic biliary system: Physiological distribution and pathological significance
スポンサーリンク
概要
- 論文の詳細を見る
Mucin secreted by mucosal epithelial cells plays a role in the protection of the mucosal surface and also is involved in pathological processes. So far, MUC1-4, 5AC, 5B, 6-8, 11-13 and 15-17 genes coding the backbone mucin core protein have been identified in humans. Their diverse physiological distribution and pathological alterations have been reported. We have studied the expression profiles of MUC genes in the intrahepatic biliary system in developmental, normal and diseased livers using immunohistochemistry and in situ hybridization. Fetal intrahepatic bile ducts and ductal plates frequently express MUC1, while intrahepatic large bile ducts after birth express mainly MUC3 mucin. In hepatolithiasis, MUC5AC (gastric foveolar epithelial type) and MUC6 (pyloric gland type) mucins are newly expressed in surface epithelial cells and proliferated peribiliary glands, respectively, and the expression of gel-forming mucin may play a role in lithogenesis. Most biliary epithelial dysplasias and cholangiocarcinomas associated with hepatolithiasis expressed MUC5AC, suggesting that intrahepatic bile ducts express the gastric foveolar phenotype during carcinogenesis. In addition, intestinal metaplasia, intraductal papillary tumor and mucinous carcinoma, characterized by MUC2 expression, are occasionally associated with hepatolithiasis in a CDX2 homeobox gene-dependent manner. These findings may suggest the presence of intestinal metaplasia-related carcinogenesis in the intrahepatic biliary system as in the stomach.
- 日本組織細胞化学会の論文
著者
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IKEDA Hiroko
Department of Anatomy and Histology, Fukushima Medical University, School of Medicine
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SASAKI Motoko
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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NAKANUMA Yasuni
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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Nakanuma Yasuni
金沢大学 医学系研究科形態機能病理学教室
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Nakanuma Yasuni
金沢大学がん研究所 腫瘍内科
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Naruse Yuchi
Fac. Of Medicine School Of Nursing Toyama Univ.
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Sasaki M
Department Of Human Pathology Kanazawa University Graduate School Of Medicine
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Sasaki Motoko
Department Of Pathology (ii) Kanazawa University School Of Medicine
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Sakurai Masaru
Dep. Of Epidemiology And Public Health Kanazawa Medical Univ.
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Nakanuma Yasuni
2nd Department Of Pathology School Of Medicine Kanazawa University
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Sasaki Motoko
Department Of Human Pathology Kanazawa University Graduate School Of Medical Science
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Sasaki Motoko
Department Of Biology Faculty Of Science Nara Women's University
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Ikeda Hiroko
Department Of Human Pathology Kanazawa University Graduate School Of Medicine
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中沼 安二
Department Of Human Pathology Kanazawa University Graduate School Of Medicine
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Nakanishi Yoshitsugu
北海道大学 医学研究科消化器内科
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Nakanuma Yasuni
Department Of Pathology School Of Medicine Kanazawa University
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Sakurai Masaru
The Department Of Endocrinology And Metabolism (first Department Of Internal Medicine) Kanazawa Univ
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Nagao Yasuyuki
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakatsuji Yoshiyuki
Department Of Pediatrics Shinshu University School Of Medicine
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Nakamura Yasuni
Second Department Of Pathology Kanazawa University School Of Medicine.
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Nakanuma Yasuni
Department Of Human Pathology Graduate School Of Medicine Kanazawa University
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Nakanishi Yoshitsugu
Department Of Surgical Oncology Division Of Cancer Medicine Hokkaido University Graduate School Of M
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Sasaki Masatoshi
Kanazawa And Department Of Surgery Saiseikai Takaoka Hospital
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Nakanuma Yasuni
Department Of Human Pathology Graduate School Of Medical Science Kanazawa University
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Ikeda Hiroko
Department Of Anatomy And Histology Fukushima Medical University School Of Medicine
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Nakayama Yoshiko
Department Of Pediatrics Shinshu University School Of Medicine
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佐々木 素子
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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