Nociception and Allodynia/Hyperalgesia Induced by Intrathecal Administration of Fenvalerate
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概要
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The intrathecal injection of fenvalerate, a sodium channel activator, at doses of 0.01 to 3 μg, dose-dependently induced the duration of a characteristic behavioral syndrome mainly consisting of reciprocal hind limb scratching directed towards caudal parts of the body and biting or licking of the hind legs in mice. Fenvalerate-induced behavior was inhibited by morphine (1 - 10 mg/kg, i.p.). The characteristic behavior was also inhibited by mexiletine, a sodium channel blocker; MK-801, a N-methyl-D-aspartate ion-channel blocker; and GR82334, a neurokinin-1-receptor antagonist. Calphostin C (3 pmol, i.t.), a protein kinase C inhibitor, inhibited fenvalerate-induced behavior. On the other hand, phorbol-12, 13-dibutyrate (50 pmol, i.t.), a protein kinase C activator, markedly enhanced the fenvalerate-induced behavior. The present results also showed that fenvalerate produced thermal allodynia and hyperalgesia in the tail-flick test. Furthermore, fenvalerate-induced thermal allodynia and hyperalgesia were inhibited by the pretreatment with calphostin C. These results suggest that the intrathecal administration of fenvalerate induces a marked nociceptive response and thermal allodynia/hyperalgesia, and they suggest that tetrodotoxin-resistant sodium channels may play an important role in this effect.
- 社団法人 日本薬理学会の論文
- 2001-07-01
著者
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Morita K
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
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Morita Kayo
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Tanaka Shun-ichi
Department Of Applied Physics Faculty Of Engineering The University Of Tokyo
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Morita Kayo
Department Of Dental Pharmacology Division Of Integrated Medical Science Hiroshima University Gradua
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ZUSHIDA Ko
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
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Zushida Ko
Department Of Pathophysiology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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SASAKI Mitsumasa
Basic Research Laboratory, HALD Inc.
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Sasaki Mitsumasa
Basic Research Laboratory Hald Inc.
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Tanaka Shun-ichi
Department Of Neurobiology Of Aging Laboratories The Mount Sinai School Of Medicine
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