Changes in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935: Possible Involvement of Noradrenergic System
スポンサーリンク
概要
- 論文の詳細を見る
We examined cross−sensitization of cocaine and synthetic local anesthetics to their seizure susceptibility after repeated administration.Seizure susceptibility of procaine and lidocaine increased after the end of two days of treatment with a subconvulsive dose of cocaine.Acute treatment with nomifensine but not GBR12935, a specific inhibitor of the dopamine transporter, facilitated lidocaine−induced convulsion.Furthermore, daily treatment with nomifensine for two days enhanced lidocaine−induced convulsion.These results suggest the possible involvement of the brain noradrenergic system in the changes in seizure susceptibility after repeated administration of some local anesthetics.
- 社団法人 日本薬理学会の論文
- 2000-07-01
著者
-
Morita Katsuya
Department of Dental Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japa
-
Dohi Toshihiro
Department of Dental Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japa
-
Dohi T
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
-
Morita Katsuya
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
-
Morita K
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
-
SATO Tomoyuki
Department of Mechanical Engineering, Ehime University
-
Morita Kayo
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
-
Sato T
Department Of Pharmacology Hiroshima University School Of Dentistry
-
Ikeda Tetsurou
Department Of Pharmacology Hiroshima University School Of Dentistry
-
KITAYAMA Shigeo
Department of Pharmacology, Hiroshima University School of Dentistry
-
Kitayama S
Department Of Dental Pharmacology Field Of Functional Physiology Branch Of Biophysiological Science
-
Kitayama Shigeo
Department Of Dental Pharmacology
-
土肥 敏博
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
-
Sato Tomoyuki
Department Of Mechanical Engineering Ehime University
-
Dohi Toshihiro
Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan
関連論文
- Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β2-Adrenergic Receptor Coupled With Protein Kinase A – cAMP Response Element Binding Protein (PKA–CREB) and Src-Tyrosine Kinase – Glycogen Synthase Kinase-3β (Src–GSK-3β)
- 7.TTP(thiamin triphosphate)によるラット線条体Dopamineの変化 : ビタミンB研究委員会 第335回会議研究発表要旨
- Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+ Rise and Migration of Human Neutrophils
- 神経伝達物質トランスポーターの構造, 機能, 発現とその制御
- Delayed Infection of a Lymphocele Following Mastectomy with Immediate Breast Reconstruction : Report of a Case
- Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca^ Rise and Migration of Human Neutrophils
- Assessing an Eating Disorder Induced by 6-OHDA and the Possibility of Nerve Regeneration Therapy by Transplantation of Neural Progenitor Cells in Rats
- 序文
- トリヘキシフェニディルによるメタンフェタミン報酬効果の抑制
- 神経伝達物質トランスポーター-神経疾患,薬物中毒に関与するその分子機構-
- Appearance of Two-Way Strain in Shape Memory Effect of Ti-Ni-Nb Alloy : Influence of Applied Strain on Two-Way Strain
- Cyclic ADP-Ribose Requires FK506-Binding Protein to Regulate Intracellular Ca^ Dynamics and Catecholamine Release in Acetylcholine-Stimulated Bovine Adrenal Chromaffin Cells
- Sutureless Anastomosis Using a Biofragmentable Anastomosis Ring
- Hirschsprung's Disease in an Adult Patient with Familial Occurrence : Report of a Case
- 万里の長城を訪ねて
- ご挨拶
- ミシガン湖のほとりで
- Changes in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935: Possible Involvement of Noradrenergic System
- Liver abscess due to Lactococcus lactis cremoris
- Solitary Fibrous Tumor in the Pelvic Cavity with Hypoglycemia : Report of a Case
- Inhaled Pinacidil, an ATP-Sensitive K+ Channel Opener, and Moguisteine Have Potent Antitussive Effects in Guinea Pig
- Focal nodular hyperplasia-like lesion of the liver in a child previously treated for nephroblastoma
- The Role of Metallothionein in Hard Tissue(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Regulated Expression and Function of the Somatodendritic Catecholamine Neurotransmitter Transporters
- Cellular and Molecular Aspects of Monoamine Neurotransmitter Transporters
- Nociception and Allodynia/Hyperalgesia Induced by Intrathecal Administration of Fenvalerate
- STIMULATION OF CATECHOLAMINE RELEASE FROM ISOLATED ADRENAL GLANDS BY SOME AMINO ACIDS
- COMPARATIVE STUDIES OF HEPATIC NICOTINE METABOLIZING ENZYME ACTIVITIES IN MONKEYS AND DOGS
- Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β_2-Adrenergic Receptor Coupled With Protein Kinase A-cAMP Response Element Binding Protein (PKA-CREB) and Src-Tyrosine Kinase-Glycogen Synthase Kinase-3β (Src-GSK-3β)
- POTENT INHIBITORY ACTION OF PILOCARPINE ON HEPATIC DRUG METABOLISM
- BIOLOGICAL ACTIVITIES OF DIAZONIUM COMPOUNDS: INDUCTION OF HYPOTHERMIA OR WRITHING BY 4 (OR 5)-DIAZOIMIDAZOLE-5 (OR 4)-CARBOXAMIDE AND THEIR ANTAGONISM BY ANALGESICS
- The anti-inflammatory effects of phenolic dental medicaments as determined by mouse ear edema assay.
- Inhibition of Lipoxygenase by Phenolic compounds.
- Regulation by Protein Kinase C of Platelet-Activating Factor- and Thapsigargin-Induced Calcium Entry in Rabbit Neutrophils.
- Stimulation-evoked cyclic nucleotides efflux from isolated perfused dog adrenals and possible involvement of calcium.
- Changes in Convulsion Susceptibility of Lidocaine by Alteration of Brain Catecholaminergic Functions.
- Involvement of Brain Serotonergic Function in Lidocaine-Induced Convulsions in Mice.
- Possible Involvement of Nitric Oxide in Acetylcholine-Induced Increase of Intracellular Ca2+ Concentration and Catecholamine Release in Bovine Adrenal Chromaffin Cells.