Involvement of Brain Serotonergic Function in Lidocaine-Induced Convulsions in Mice.
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概要
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Influences of drug-induced manipulations of central serotonergic function on lidocaine- and pentylenetetrazol (PTZ)-induced convulsions were examined in mice. Agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-HT) function decreased the incidence of lidocaine-induced convulsions. These treatments had similar influences on the incidence of PTZ-induced convulsions. Lidocaine (10<SUP>-5</SUP>-10<SUP>-3</SUP>M) reduced the stimulation evoked [<SUP>3</SUP>H]5-HT release from cortical slices, followed with an increased spontaneous [<SUP>3</SUP>H] overflow at higher concentrations. These results may suggest that brain 5-HT neurons are causally involved as inhibitory neurons in lidocaine-induced convulsions as in the case of PTZ-induced convulsions.
- 公益社団法人 日本薬理学会の論文
著者
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Morita Katsuya
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
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TSUJIMOTO Akira
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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TAKADA Kazuaki
Department of Oral & Maxillo-facial Surgery 1, Hiroshima University School of Dentistry
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Uchiyama Yoshiko
Department Of Advanced Materials Science Graduate School Of Frontier Sciences The University Of Toky
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Endo Kunihiko
Department of Earth Sciences, Nihon University
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Dohi Toshihiro
Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan
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Uchiyama Yoshiko
Department of Pharmacology, Hiroshima University School of Dentistry
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Takada Kazuaki
Department of Oral and Maxillofacial Surgery I, Hiroshima University School of Dentistry,
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