The anti-inflammatory effects of phenolic dental medicaments as determined by mouse ear edema assay.

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概要

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• The anti-inflammatory effects of phenolic dental medicaments were evaluated by mouse ear edema assay. p-Chlorophenol (PCP) inhibited edema when applied topically in dosages of 0.2 and 0.5 mg per site at 15 min before or 1.0 and 2.0 mg per site at 60 min after the application of croton oil. The inhibitory effects were also noted with eugenol, guaiacol, o-cresol, phenol and orally administered indomethacin (10 mg/kg). The involvement of the effects on prostaglandin biosynthesis in the anti-inflammatory effects of these compounds is discussed.

著者

• TSUJIMOTO Akira

  Department of Electronic Engineering, Faculty of Engineering, Osaka University

• Terada Hiroshi

  Department Of Applied Biological Sciences Faculty Of Agricultural Science Nagoya University

• Okamoto Hiroshi

  Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku

• Dohi Toshihiro

  Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan

• ANAMURA Shinichi

  Department of Endodontology and Periodontology, Hiroshima University School of Dentistry

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