Changes in Convulsion Susceptibility of Lidocaine by Alteration of Brain Catecholaminergic Functions.
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概要
- 論文の詳細を見る
Influences of the manipulation of brain catecholaminergic neuronal activity on the incidence of lidocaine-induced convulsions in mice were studied and compared with those of pentylenetetrazol (PTZ)-induced convulsions. α-Methyl-p-tyrosine (α-MPT) decreased both brain noradrenaline (NA) and dopamine (DA) levels, and disulfiram decreased the NA level and increased the DA level. The incidence of lidocaine-induced convulsions was decreased by treatments with α-MPT and disulfiram, while that of PTZ was increased by either treatment. The incidence of lidocaine-induced convulsions was slightly, but not significantly increased by L-dihydroxyphenylalanine (L-DOPA), although the brain DA level was increased by L-DOPA. Methamphetamine and desipramine increased the incidences of lidocaine-induced convulsions. These results may suggest that brain catecholaminergic neurons, differing from their role in inhibiting control of PTZ-seizure, act to facilitate lidocaine-induced convulsions.
- 公益社団法人 日本薬理学会の論文
著者
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TSUJIMOTO Akira
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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TAKADA Kazuaki
Department of Oral & Maxillo-facial Surgery 1, Hiroshima University School of Dentistry
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Dohi Toshihiro
Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan
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Yoshimura Yoshimichi
Department of Oral and Maxillofacial Surgery I, Hiroshima University School of Dentistry
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Takada Kazuaki
Department of Oral and Maxillofacial Surgery I, Hiroshima University School of Dentistry
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Tanaka Shoukichi
Kure National Hospital, Department of Pharmacy
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