Cellular and Molecular Aspects of Monoamine Neurotransmitter Transporters
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概要
- 論文の詳細を見る
Neurotransmitter transporters terminate synaptic neurotransmission by accumulating neurotransmitters once again after release in a sodium- and chloride-dependent fashion. The availability of the cloned neurotransmitter transporters has allowed investigation into the roles of these transporters in neuronal function. Molecular biological and protein engineering studies including in vitro site-directed mutagenesis, chimera formation of several transporter clones, or epitope-tagging various regions of transporter proteins, have revealed the topology and functionally mapped the transporter proteins. Monoamine neurotransmitter transporters such as those for dopamine, norepinephrine and serotonin are of interest, since they are a target of drugs of abuse and are involved in neuronal disorders including Parkinsons disease and depression. Therefore, elucidating the molecular basis of these transporters may clarify these problems and help develop treatments with which to combat these disorders and drug abuse.
- 社団法人 日本薬理学会の論文
- 1996-11-01
著者
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Dohi Toshihiro
Department of Dental Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japa
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Dohi Toshihiro
Department Of Pharmacology Hiroshima University School Of Dentistry
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Kitayama Shigeo
Department Of Dental Pharmacology
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Kitayama Shigeo
Department Of Pharmacology Hiroshima University School Of Dentistry
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Dohi Toshihiro
Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan
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