Possible Involvement of Nitric Oxide in Acetylcholine-Induced Increase of Intracellular Ca2+ Concentration and Catecholamine Release in Bovine Adrenal Chromaffin Cells.
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概要
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The role of nitric oxide (NO) in neurotransmitter release was studied using bovine adrenal medullary chromaffin cells. L-Arginine and sodium nitroprusside (SNP) slightly increased the intracellular free calcium concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>), and the effects of the agents were dependent on the presence of the extracellular Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]<SUB>o</SUB>), but were not blocked by verapamil (30 μM) or diltiazem (30 μM). SNP enhanced the acetylcholine (ACh)-induced rise in [Ca<SUP>2+</SUP>]<SUB>i</SUB> in the presence but not in the absence of [Ca<SUP>2+</SUP>]<SUB>o</SUB>. The effects of L-arginine but not those of SNP were inhibited by <I>N<SUP>ω</SUP></I>-nitro-L-arginine (L-NNA). L-NNA significantly reduced the ACh-induced rise in [Ca<SUP>2+</SUP>]<SUB>i</SUB> and catecholamine (CA) release, and the reduction was restored by L-arginine but not by D-arginine. These results suggest a possible involvement of NO in ACh-induced [Ca<SUP>2+</SUP>]<SUB>i</SUB> rise and CA release in bovine adrenal chromaffin cells.
- 公益社団法人 日本薬理学会の論文
著者
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Minami Naoki
Department Of Applied Quantum Physics And Nuclear Engineering Graduate School Of Engineering Kyushu
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Morita Katsuya
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
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Kitayama Shigeo
Department Of Dental Pharmacology
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Uchiyama Yoshiko
Department Of Advanced Materials Science Graduate School Of Frontier Sciences The University Of Toky
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Dohi Toshihiro
Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Japan
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Suemitsu Tetsuo
Department of Pharmacology, Hiroshima University School of Dentistry
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Miyasako Takanori
Department of Pharmacology, Hiroshima University School of Dentistry
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- Possible Involvement of Nitric Oxide in Acetylcholine-Induced Increase of Intracellular Ca2+ Concentration and Catecholamine Release in Bovine Adrenal Chromaffin Cells.