Tissue-Specific Expression of Rat Kininogen mRNAs
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概要
- 論文の詳細を見る
To characterize the local kallikrein-kinin system, tissue distribution of mRNAs for kininogens, precursor proteins of kinins, such as high-molecular-weight (H-), low-molecular-weight (L-) and T-kininogens, were studied in the rat by means of reverse-transcription polymerase chain reaction (RT-PCR) using a fluorophore Cy5-labeled 5'-primer. High levels of these three kininogen mRNAs were present in the liver. Relatively high levels of H-kininogen mRNA were also detected in the skin, lung, kidney, and testis in a descending order, whereas L-kininogen mRNA was detectable in the lung and brain, but not in the kidney, skin testis, heart, adrenal gland, or skeletal muscle. T-Kininogen mRNA was present in these tissues, except for skeletal muscle. These findings suggest that the expression of each kininogen mRNA is regulated by the tissue-dependent mechanisms which is closely associated with functions of the kallikrein-kinin system in the tissue.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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Okamoto Hiroshi
Department Of Cardiovascular Medicine Hokkaido University Hospital
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屋山 勝俊
神戸学院大学薬学部 生命薬学部門 循環器薬理学研究室
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Takano M
Tohoku Pharmaceutical University
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鷹野 正興
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Okamoto H
Department Of Systems Innovation Graduate School Of Engineering Science Osaka University
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Okamoto H
Ntt Optoelectronics Kanagawa Jpn
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松井 貴史
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Okamaoto H
Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive
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Takano M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences And High Technology Research Center
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Okamoto H
Department Of Systems And Control Engineering Anan National College Of Technology
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YAYAMA Katsutoshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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TAKANO Masaoki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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SAKANAKA Fumie
Department of Pharmacology, Faculty of Pharmaceutical Sciences and High Technology Research Center
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Sakanaka Fumie
Department Of Pharmacology Faculty Of Pharmaceutical Sciences And High Technology Research Center
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岡本 宏巳
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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屋山 勝俊
Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive
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Okamoto Hiroshi
Department Of Advanced Materials Science Graduate School Of Frontier Sciences University Of Tokyo:cr
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Yayama Katsutoshi
Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive
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Okamoto Hiroshi
Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive
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Okamoto Hiroshi
Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku
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Takano Masaoki
Department of Life Science Pharmacy, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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