The Studies of Cell Damaging and Cell Growth Factors which Induce Cardiomyopathy : MOLECULAR ANALYSIS OF THE PATHOPHYSIOLOGY OF CARDIOMYPATHY
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概要
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We demonstrated that phosphatidylinositide-specific phospholipase C (PLC) activity was greater in cardiomyopathic hamster hearts (BIO 14.6 and BIO 53.58) then in hamster controls (F1b). Inositol trisphosphate (IP_3) production was markedly greater in both of the cardiomyopathic hamsters, BIO 14.6 and BIO 53.58. We have also determined the sarcoplasmic reticulum (SR) function of heart. Calcium uptake into SR markedly increased in BIO 14.6. On the other hand, it significantly decreased in BIO 53.58 compared with F1b. It is well known that IP_3 stimulates calcium release from SR. In BIO 14.6, calcium relrease from SR stimulated by IP_3 increased, but its effect decreased in BIO 53.58 compared with F1b. These results suggest that PI response may produce high intracellular calcium levels in both BIO 14.6 and BIO 53.58 myocytes. In addition, in the BIO 53.58 hamster the sarcoplasmic reticulum deteriorate in function. It was concluded from these results that a prolonged high intracellular calcium level may lead to the death of BIO 53.58 myocytes. The expression of angiotensinogen mRNA was observed in the hamster heart. There was no differences in its expression level between F1b, BIO 14.6 and BIO 53.58. There was no effect of ages on its expression in these hamster hearts. We have also determined the distribution of angiotensinogen in these hamsters. At 4 weeks of age, the immunohistochemical study revealed that angiotensinogen was widely distributed in subendcardium in these hamsters. There was no difference in its distribution between F1b, BIO 14.6 and BIO 53.58. But at 20 weeks old of age its immunoreactivity decreased in BIO 53.58. There was no effect of age on its reactivity in F1b and BIO 14.6. We have detected angiotensinogen in heart, but its role is still not clear. A further study should be done to clarify its role in cardiac hypertrophy and cell damage.
- 社団法人日本循環器学会の論文
- 1992-10-20
著者
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Okamoto Hiroshi
Department Of Cardiovascular Medicine Hokkaido University Hospital
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Sawa Hirofumi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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SANO HITOSHI
Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical
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Kawaguchi Hideaki
Department of Laboratory Medicine, Hokkaido University Graduate School of Medicine
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Kudo Toshiyuki
Department of Clinical Pharmacokinetics, School of Pharmacy and Pharmaceutical Sciences, Hoshi Unive
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Sano Hitoshi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Kudo Toshiyuki
Department Of Biological Pharmacy School Of Pharmacy Shujitsu University
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Kudo Toshiyuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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SHOKI MIKAKO
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
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SAKATA YOSHIHITO
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
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YASUDA HISAKAZU
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
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Kawaguchi Hideaki
Hokkaido University
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Yasuda Hisakazu
Hokkaido University
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Shoki Mikako
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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SAWA Hirofumi
21st Century COE Program for Zoonosis Control
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Yasuda Hisakazu
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine Sapporo Japan
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Yasuda Hisakazu
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Yasuda Hisakazu
Department Of Cardiology Hokkaido University School Of Medicine Sapporo
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Okamoto Hiroshi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Sakata Yoshihito
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Kawaguchi Hideaki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Kawaguchi Hideaki
Department Of Cardiovascular Medicine Hokkaido University
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Yasuda Hisakazu
Department Of Cardiovascular Medicine Hokkaido Univcrsity
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Okada Hitoshi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Yasuda Hisakazu
Department Of Cardiology Hokkaido University School Of Medicine
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Okamoto Hiroshi
Department Of Advanced Materials Science Graduate School Of Frontier Sciences University Of Tokyo:cr
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Okamoto Hiroshi
Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku
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Yasuda Hisakazu
Department O F Cardiovascular Medicine Hokkaido University School Of Medicine
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