Serum Amyloid A, Cytokines, and Corticosterone Responses in Germfree and Conventional Mice after Lipopolysaccharide Injection
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概要
- 論文の詳細を見る
To determine why germfree mice are less susceptible to lipopolysaccharide (LPS) than conventional mice, we studied serum levels of serum amyloid A (SAA), tumor necrosis factor (TNF), interleukin 1 (IL-1), IL-6,and corticosterone in mice after treatment with LPS. A single injection of LPS caused an elevation of SAA, an acute-phase protein in the mouse, in both conventional and germfree IQI mice, and the response was significantly less in germfree mice. LPS-induced elevations of serum TNF, IL-1,and IL-6 levels were also significantly less in germfree mice, while serum corticosterone levels were greater in germfree mice than in conventional mice. These results suggest that the lower susceptibility to LPS and a smaller response of SAA elevation by LPS in germfree mice may result from less elevation in serum of these cytokines in these mice, which are known to mediate the acute phase response of SAA. High levels of serum corticosterone in germfree mice may be partly responsible for the lower responsiveness of these inflammatory cytokines to LPS in these mice.
- 社団法人日本農芸化学会の論文
- 1999-06-23
著者
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Okamoto Hiroshi
Department Of Cardiovascular Medicine Hokkaido University Hospital
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HAMADA Kazuya
Department of Neurosurgery, Kumamoto National Hospital
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Hamada Kazuya
Department Of Nutritional Pathology Faculty Of Nutrition
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Ikeda Masamichi
Department Of Nutritional Pathology Faculty Of Nutrition
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SUMITOMO Naomi
Department of Nutritional Pathology, Faculty of Nutrition
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SAKAKIBARA Bunsaku
Department of Nutritional Pathology, Faculty of Nutrition
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Sumitomo Naomi
Department Of Nutritional Pathology Faculty Of Nutrition
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Sakakibara B
Department Of Nutritional Pathology Faculty Of Nutrition
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Okamoto Hiroshi
Department Of Advanced Materials Science Graduate School Of Frontier Sciences University Of Tokyo:cr
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Okamoto Hiroshi
Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku
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