PHOSPHATIDYLINOSITOL AND INOSITOLPHOSPHATIDE METABOLISM IN HYPERTROPHIED RAT HEART

概要

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The accumulation of both Inositol-(1,4,5)-trisphosphate (IP_3) and Inositol-(1,3,4,5)-tetrakisphosphate (IP_4) after hormonal stimulation has a physiological role, possibly in altering Ca^<2+> levels in cardiac tissue. However, the accumulation of inositol polyphosphate under pathophysiological conditions has not been studied. In our experiments the metabolism of phatidylinositol and IP_3 m cardiac myocytes as investigated. It was shown that basal levels of cytosolic phosphatidylinositol specific phospholipase C (PI-PLC), phosphatidylinositol-(4,5)-bisphosphate specific phospholipase C (PIP_2-PLC) activities markedly increased in stroke-prone spontaneously hypertensive rats (SHRSP) with age compared with age matched Wistar Kyoto rats (WKY). IP_3 kinase and IP_3 phosphatase activities also increased in SHRSP hearts with age. Their activities increased in WKY, but to a lesser antent than in SHRSPs. These data suggest that a PI turnover pathway such as the phosphatidylinositol 4,5-bisphosphate-IP_3-Ca^<2+> pathway or the diacylglyceride-protein kinase C pathway may have an important role in the development of hypertrophy in SHRSP heart.
社団法人日本循環器学会の論文
1992-02-20