Angiotensinogen Synthesis in the Liver Is Independent of Physiological Estrogen Levels
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概要
- 論文の詳細を見る
We determined the physiological importance of endogenous estrogen in the regulation of angiotensinogen synthesis in the liver. The plasma levels of angiotensinogen and hepatic levels of angiotensinogen mRNA were studied in the rat in comparison to those of T-kininogen, a plasma protein whose synthesis in the liver is primarily estrogen-dependent. Plasma levels of T-kininogen and hepatic levels of T-kininogen mRNA were 3- and 2-fold higher in adult females, respectively, than in adult males, whereas there were no sex differences in levels of either plasma angiotensinogen or hepatic angiotensinogen mRNA. Ovariectomy in female rats abolished the sex differences in the levels of plasma T-kininogen and hepatic T-kininogen mRNA, but it did not affect those of plasma angiotensinogen and hepatic angiotensinogen mRNA. These results suggest that, in contrast to T-kininogen, angiotensinogen synthesis in the liver is unlikely to be controlled by endogenous levels of estrogen.
- 社団法人日本薬学会の論文
- 1995-01-15
著者
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岡本 博
神戸学院大学薬学部 生命薬学部門 循環器薬理学研究室
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屋山 勝俊
神戸学院大学薬学部 生命薬学部門 循環器薬理学研究室
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屋山 勝俊
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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鷹野 正興
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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岡本 博
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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王 爾民
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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岡本 孝吉
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Takano M
Tohoku Pharmaceutical University
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鷹野 正興
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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王 爾民
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University:(present Addres
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松井 貴史
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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岡本 孝吉
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Okamoto H
Faculty Of Pharmacy Meijo University
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Takano M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences And High Technology Research Center
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屋山 勝俊
Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive
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Yayama Katsutoshi
Laboratory Of Cardiovascular Pharmacology Department Of Biopharmaceutical Sciences Kobe Gakuin Unive
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