Population Pharmacokinetics of Phenytoin in Japanese Patients with Epilepsy : Analysis with a Dose-Dependent Clearance Model
スポンサーリンク
概要
- 論文の詳細を見る
The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients. The 531 serum concentration values at steady-state after repetitive oral administration were analyzed using a nonlinear mixed effects model (NONMEM) program designed for estimation of population pharmacokinetic parameters. A one-compartment model with dose-dependent clearance was used for the pharmacokinetic analysis of phenytoin. The volume of distribution (V) was estimated to be 1.23l/kg in a typical 42-kg patient, assuming that the bioavailability of orally administered phenytoin is 100%. The maximal elimination rate (V_<max>) and the Michaelis-Menten constant (K_m) were 9.80mg/d/kg and 9.19μg/ml, respectively. The parameter of power function of weight to adjust V and V_<max> was estimated to be 0.463. In addition, K_m for phenytoin appeared to be 16% increased in patients receiving zonisamide concurrently. The population pharmacokinetic parameters of phenytoin will be useful for designing dosage regimens in epileptic patients.
- 社団法人日本薬学会の論文
- 1996-03-15
著者
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YASUHARA Masato
Department of Pharmacy, Post Graduate School, Tokyo Medical and Dental University
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TAKANO Mikihisa
Department of Pharmaceutics and Therapeutics, Division of Clinical Pharmaceutical Science, Programs
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HATTORI Haruo
Department of Pediatrics, Kyoto University Faculty of Medicine
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Takano M
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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OTSUKI Yuko
Department of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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FURUSHO Kenshi
Department of Pediatrics, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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INUI Kenichi
Department of Pharmacy Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Hattori Haruo
Department Of Pediatrics Faculty Of Medicine Kyoto University
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Hattori Haruo
Department Of Pediatrics Kyoto University Hospital Faculty Of Medicine Kyoto University
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Takano M
Tohoku Pharmaceutical University
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鷹野 正興
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Yasuhara Masato
Department Of Hospital Pharmacy School Of Medicine Tokyo Medical And Dental University
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Hashimoto Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yasuhara M
Tokyo Medical And Dental Univ. Tokyo Jpn
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松井 貴史
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takano M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences And High Technology Research Center
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Furusho Kenshi
Department Of Pediatrics Faculty Of Medicine Kyoto University Japan
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Furusho Kenshi
Department Of Pediatrics Kyoto University Hospital Faculty Of Medicine Kyoto University
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Otsuki Yuko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Hashimoto Yukiya
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Inui Kenichi
Department Of Pharmacy Kyoto University Hospital
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Inui Ken‐ichi
Kyoto Univ. Hospital Kyoto Jpn
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Inui Ken-ichi
Department Of Pharmacy Faculty Of Medicine Kyoto University Hospital Kyoto University
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Hashimoto Y
Institute Of Molecular & Cellular Biosciences The University Of Tokyo
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Takano Mikihisa
Department Of Pharmaceutics And Therapeutics Graduate School Of Biomedical Sciences Hiroshima Univer
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