α-Glucosidase Inhibitors with a Phthalimide Skeleton : Stucture-Activity Relationship Study

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概要

• 論文の詳細を見る

• α-Glucosidase inhibitors with a phthalimide skeleton were prepared. Structure-activity relationship studies indicated a critical role for the hydrophobicity of the substituent at the nitrogen atom of the phthalimide skeleton. Introduction of electron-withdrawing groups, including a nitro group and chlorine, influenced the activity.Optimization studies led us to design 4,5,6,7-tetrachloro-N-phenylphthalimide (CP0P) and its N-phenylalkyl derivatives. CP0P and 4,5,6,7-tetrachloro-N-(4-phenylbutyl)phthalimide (CP4P) proved to be more potent α-glucosidase inhibitors than the known inhibitor 1-deoxynojirimycin.

• 公益社団法人日本薬学会の論文
• 2000-10-01

著者

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Hashimoto Yuichi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• SODEOKA Mikiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• SOU Sonei

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• TAKAHASHI Hiroyasu

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• YAMASAKI Ryu

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• 山崎 亮治

  徳大医公衛

• Takahashi H

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Sou Sonei

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Yamasaki R

  Graduate School Of Pharmaceutical Sciences University Of Tokyo

• Sodeoka Mikiko

  Sagami Chemical Research Center

• Takahashi Hiroyasu

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Takahashi Hiroyasu

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sodeoka Mikiko

  Institute for Chemical Reaction Science, Tohoku University

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