Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis

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概要

• 論文の詳細を見る

• Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3, 5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on HL-60 cells and anti-angio-genic activity on human umbilical vein endothelial cells (HUVEC). AIDO-00 (7) also showed anti-angiogenic activity. NIDO-11 (8) showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation, and AIDO-30 (13) exhibited cyclooxygenase (COX)-inhibitory activity.

• 公益社団法人日本薬学会の論文
• 2006-06-01

著者

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• KOBAYASHI Hisayoshi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• MIYACHI Hiroyuki

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Kobayashi H

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Univ. Tokyo Tokyo Jpn

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• 中山 太ニ

  岡山大学薬学部薬剤学教室

• FUJIMOTO Haruka

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• NOGUCHI Tomomi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Miyachi Hiroyuki

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular And Cellular Biosciences The Universityv Of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Noguchi T

  Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.

• Miyachi H

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Miyachi Hiroyuki

  Div. Of Pharmaceutical Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Noguchi-yachide Tomomi

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Fujimoto Haruka

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

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